Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae Pneumonia.
Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae Pneumonia.
复制标题
DOI：
10.5812/ijp.3807
复制
发表时间：
2016-02
影响因子：
0.5
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Li W;Liu YJ;Zhao XL;Shang SQ;Wu L;Ye Q;Xu H
肺炎患儿病原体感染时 Th1/Th2 细胞因子水平可能发生变化。评价Th1/Th2细胞因子谱及其对儿童肺炎支原体肺炎的诊断价值。对肺炎支原体单一感染儿童和30名健康儿童进行细胞因子测定。我们使用实时 PCR 来检测肺炎儿童中的肺炎支原体。 13161名肺炎儿童中，2188名（16.62%）肺炎支原体检测呈阳性。 5～9岁儿童发病率最高，夏季是浙江省肺炎支原体发病的高发季节。研究过程中，对526名肺炎支原体单一感染的肺炎儿童和30名健康儿童进行了细胞因子测定。肺炎支原体肺炎儿童IL-2水平低于健康儿童（中位水平，pg/mL：IL-2：3.2 vs. 5.7，P = 0.00），而IL-4、IL-10和IFN-γ水平高于健康儿童（中位水平，pg/mL：IL-4：3.2 vs. 1.5，P = 0.00；IL-10：5.6 vs. 1.5）。 2.5，P = 0.001；IFN-γ：20.4 与 4.8，P = 0.001）。肺炎支原体肺炎患儿IL-2降低，IL-4、IL-10、IFN-γ升高，在临床诊断该病方面具有广阔的前景。
The levels of Th1/Th2 cytokine can alter in pathogenic infection in children with pneumonia. To evaluate Th1/Th2 cytokine profile and its diagnostic value in M. pneumoniae pneumonia in children. Children with M. pneumoniae mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae in children with pneumonia. M. pneumoniae test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001). IL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice.