Helicobacter pylori in the oral cavity is associated with gastroesophageal disease
Helicobacter pylori in the oral cavity is associated with gastroesophageal disease
复制标题
DOI：
10.1111/j.1399-302x.2009.00541.x
复制
发表时间：
2009-12-01
影响因子：
--
通讯作者：
Cravioto, A.
中科院分区：
文献类型：
--
作者：
Morales-Espinosa, R.;Fernandez-Presas, A.;Cravioto, A.
背景：在墨西哥，80%以上的人口感染幽门螺杆菌。口腔中幽门螺杆菌的检出频率尚不清楚，其与胃食管病理的关系。目的：通过PCR检测墨西哥人群口腔中幽门螺杆菌的存在，并确定其与胃食管疾病的关系。方法：将患者分为两组，根据不同的临床情况，采集胃活检、牙菌斑和唾液样本。 并进行了分析。第一组由住院患者组成，其中大多数被诊断患有胃食管疾病，而第二组选自牙科诊所（流动人群），其中大多数似乎是健康受试者。 结果：H.使用一组针对空泡细胞毒素基因信号序列的特异性引物，通过 PCR 在胃活检、牙菌斑和唾液样本中检测到幽门螺杆菌；一般来说，胃活检和牙菌斑样本中幽门螺杆菌的检出率高于唾液样本。口腔中检出幽门螺杆菌与患有胃食管疾病的患者显着相关（P = 0.0001），而健康受试者和患有其他非胃病的人口腔中不存在幽门螺杆菌。口腔中幽门螺杆菌的检测与胃食管疾病有关。此外，建议所有出现胃部症状且口腔检出幽门螺杆菌的患者立即开始细菌治疗。
Background:In Mexico, more than 80% of the population is infected with Helicobacter pylori. The frequency of H. pylori detection in the oral cavity is unknown, as its relationship with gastroesophageal pathology.Aim:To detect the presence of H. pylori in the oral cavity in Mexican population by PCR and to determine its association with gastroesophageal disease.Methods:Patients were divided into two groups with different clinic conditions from whom gastric biopsy, dental plaque, and saliva samples were taken and analyzed. The first group comprised of hospitalized patients, the majority of whom were diagnosed with gastroesophageal disease, while the second group was selected from a dental clinic (ambulatory population) the majority of whom appeared to be healthy subjects.Results:H. pylori was detected in gastric biopsy, dental plaque and saliva samples by PCR using a set of specific primers for the signal sequence of the vacuolating cytotoxin gene; detection of H. pylori in general was higher in gastric biopsy and dental plaque samples than in saliva samples. Detection of H. pylori in the oral cavity is significantly (P = 0.0001) associated with patients presenting gastroesophageal disease, while healthy subjects and those with other non-gastric disease do not present with H. pylori in their oral cavity.Conclusions:H. pylori detection in the oral cavity is associated to gastroesophageal disease. In addition, it is suggested that all patients presenting gastric symptoms and H. pylori detection in the oral cavity would begin bacterial treatment immediately.