Validation of the EQ-5D in patients with a history of acute coronary syndrome
Validation of the EQ-5D in patients with a history of acute coronary syndrome
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DOI：
10.1185/030079905x56349
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发表时间：
2005-08-01
影响因子：
2.3
通讯作者：
Erickson, SR
中科院分区：
文献类型：
--
作者：
Ellis, JJ;Eagle, KA;Erickson, SR
目的：目的：分析EQ-5D在急性冠脉综合征（ACS）患者中的结构效度。方法：对某大学附属医院3年内出院的ACS患者进行EQ-5D和SF-8问卷调查。EQ-5D包括用于测量自我报告的当前健康状况（0-100）的视觉模拟量表（EQ VAS）和用于测量活动性、自我护理、日常活动、疼痛/不适和焦虑/抑郁的五项描述性系统。还包括疾病严重程度的措施[杜克活动状态指数（DASI），心脏症状计数（SC），病人认为心脏疾病的严重程度]，合并症的措施（Charlson合并症指数，总药物计数），和其他人口统计学和疾病相关的items.Results：1217例患者，490（40.3%）响应。患者平均年龄为65.2岁（SD 11.3）; 71.0%为男性; 91.9%为白人; 64.3%有MI病史。只有0.2%-0.4%的EQ-5D项目和8%的EQ VAS未被受访者回答。根据5项EQ-5D评分确定了9种最常见的健康状态。与重度/极重度患者、合并症较低的患者、症状缓解较低的患者和心脏相关功能较高的患者相比，极轻度/轻度感知疾病严重程度患者的EQ-5D项目应答水平和EQ VAS评分显著更好。EQ VAS评分和SF-8子量表评分的相关系数范围为0.527至0.798（均p < 0.0001）。个体EQ-5D项目的反应水平和可比SF-8 subscales.Conclusions分数之间存在显着差异：本研究表明，在以人群为基础的样本中，具有ACS病史的患者的EQ-5D的结构效度。
Objective: To analyze the construct validity of the EQ-5D in patients with acute coronary syndromes (ACS).Methods: All ACS-diagnosed patients discharged from a university-affiliated hospital during a 3-year period were mailed a questionnaire that included the EQ-5D and the SF-8. The EQ-5D includes a visual analogue scale (EQ VAS) to measure self-reported current health-status (0-100) and a five-item descriptive system measuring mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Also included were disease severity measures [Duke Activity Status Index (DASI), cardiac symptom count (SC), patient-perceived cardiac disease severity], comorbidity measures (Charlson comorbidity index, total medication count), and other demographic and disease-related items.Results: Of 1217 patients, 490 (40.3%) responded. Patients averaged 65.2 (SD 11.3) years of age; 71.0% male; 91.9% Caucasian; 64.3% history of MI. Only 0.2%-0.4% of EQ-5D items and 8% of the EQ VAS were left unanswered by respondents. The nine most common health states were identified based on the five EQ-5D item scores. Levels of responses to EQ-5D items and the EQ VAS score were significantly better for patients with very mild/mild perceived disease severity compared to severe/very severe, for patients with lower comorbidity, for patients with lower symptom responses, and for patients with a higher cardiac-related functioning. EQ VAS score and SF-8 subscale score correlation coefficients ranged from 0.527 to 0.798 (all p < 0.0001). Significant differences were observed between the response level of individual EQ-5D items and scores of comparable SF-8 subscales.Conclusions: This study demonstrated the construct validity of the EQ-5D in a population-based sample of patients with a history of ACS.