The Longitudinal Effects of Blood Pressure and Hypertension on Neurocognitive Performance in People Living With HIV.
The Longitudinal Effects of Blood Pressure and Hypertension on Neurocognitive Performance in People Living With HIV.
复制标题
血压和高血压对HIV患者神经认知性能的纵向影响。
DOI：
10.1097/qai.0000000000002740
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Manhattan HIV Brain Bank
中科院分区：
文献类型：
--
作者：
Guzman VA;Cham H;Gutierrez J;Byrd D;Morris EP;Tureson K;Morgello S;Mindt MR;Manhattan HIV Brain Bank
高血压和艾滋病毒是脑血管疾病和神经认知障碍的显著危险因素，但高血压对艾滋病毒感染者神经认知表现的影响仍知之甚少。这是第一个研究HIV感染者血压、高血压和脉压与神经认知表现之间纵向关系的研究。对曼哈顿HIV脑库收集的485名HIV阳性参与者的医学、神经认知和病毒学数据进行分析，这是一项前瞻性、观察性、纵向的神经HIV研究。估计血压、高血压状态和脉压的一系列具有随机截距和斜率的多水平线性增长曲线模型，以预测神经认知表现的变化。高血压的基线患病率为23%。舒张压和收缩压的纵向变化分别与凹槽钉板测试非优势手表现增加10.5秒和4秒相关。舒张压的纵向变化也与糖尿病有关。在威斯康星卡片分类测试中，正确类别下降3个百分点，持久性反应和总错误增加3个百分点。高血压流行和/或偶发的几率增加与a。正确类别减少1分，a。威斯康星卡片分类测试的总错误增加了8个点。脉压和神经认知表现之间没有关联。结果表明，血压和高血压与较差的神经认知测试表现呈线性纵向关系，特别是在艾滋病毒感染者的精神运动和执行功能方面。
Hypertension and HIV are salient risk factors for cerebral small vessel disease and neurocognitive impairment, yet the effects of hypertension on neurocognitive performance in persons living with HIV remain poorly understood. This is the first study to examine the longitudinal associations between blood pressure, hypertension, and pulse pressure with neurocognitive performance in persons living with HIV. New York City Analysis of medical, neurocognitive, and virologic data from 485 HIV+ participants collected by the Manhattan HIV Brain Bank, a prospective, observational, longitudinal study of neuroHIV. A series of multilevel linear growth curve models with random intercepts and slopes were estimated for blood pressure, hypertension status, and pulse pressure to predict change in neurocognitive performance. The baseline prevalence of hypertension was 23%. Longitudinal change in diastolic and systolic pressure were associated with 10.5-second and 4-second increase in Grooved Pegboard Test non-dominant hand performance, respectively. Longitudinal change in diastolic blood pressure was also associated a .3-point decline in correct categories and 3-point increase in perseverative responses and total errors on the Wisconsin Card Sorting Test. Increasing odds of prevalent and/or incident hypertension was associated with a .1-point decrease in correct categories and a .8-point increase in total errors on the Wisconsin Card Sorting Test. There was no association between pulse pressure and neurocognitive performance. Results indicate linear longitudinal relations for blood pressure and hypertension with poorer neurocognitive test performance, particularly in psychomotor and executive functions in persons with HIV.
影响因子：
3.2
作者：
Gutierrez J;Murray J;Chon C;Morgello S
通讯作者：
Morgello S