Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthma-猫眼课题宝

皮质类固醇治疗对哮喘受试者单核细胞白介素α1和肿瘤坏死因子分泌的影响

DOI：

发表时间：

1992

期刊：

Clinical and Experimental Allergy

影响因子：

6.1

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

A. Vecchiarelli;Andrea Siracusa;E. Cenci;M. Puliti;Giuseppe Abbritti

Peripheral blood monocytes (PBM) may be activated in asthmatic patients, a condition usually reverted by corticosteroid (CS) treatment. In the present research we have evaluated the spontaneous or lipopolysaccharide (LPS)‐induced production of interleukin 1 (IL‐1) and tumour necrosis factor (TNF) by PBM obtained from 14 asthmatic subjects during an asthmatic attack and after 1 week of CS treatment. The control group included 20 healthy volunteers. PBM obtained during severe asthma showed a pattern of IL‐1 and TNF secretion similar to that of normal subjects. After CS treatment, IL‐1 levels did not change significantly in comparison to baseline values, while LPS‐induced TNF production was apparently related to the degree of airway obstruction after CS treatment. In fact, TNF production by PBM from CS‐responsive subjects was significantly decreased in comparison to the levels determined before CS treatment, while PBM from CS‐resistant subjects produced the same cytokine levels regardless of CS treatment. The present study suggests that the determination of LPS‐induced TNF secretion by PBM could be used to confirm the effectiveness of CS treatment in asthma.