Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.
Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.
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DOI：
10.1101/lm.040253.115
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Cooper MA
中科院分区：
文献类型：
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作者：
Dulka BN;Ford EC;Lee MA;Donnell NJ;Goode TD;Prosser R;Cooper MA
脑源性神经营养因子（BDNF）对于记忆过程至关重要。本研究测试了基底外侧杏仁核 (BLA) 内 proBDNF 蛋白水解为成熟 BDNF (mBDNF) 是否调节失败相关记忆的巩固。我们发现，严重的社交失败会增加 BLA/中央杏仁核中 mBDNF 的表达，但不会增加 proBDNF 的表达。我们还表明，在社交失败后立即通过显微注射α2-抗纤溶酶来阻断 BLA 中的纤溶酶，可减少 24 小时后的社交回避。这些数据表明 BLA 中 BDNF 的蛋白水解裂解对于失败引起的社交回避是必要的。
Brain-derived neurotrophic factor (BDNF) is essential for memory processes. The present study tested whether proteolytic cleavage of proBDNF into mature BDNF (mBDNF) within the basolateral amygdala (BLA) regulates the consolidation of defeat-related memories. We found that acute social defeat increases the expression of mBDNF, but not proBDNF, in the BLA/central amygdala. We also showed that blocking plasmin in the BLA with microinjection of α2-antiplasmin immediately following social defeat decreases social avoidance 24 h later. These data suggest the proteolytic cleavage of BDNF in the BLA is necessary for defeat-induced social avoidance.