HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION
HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION
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DOI：
10.1016/0140-6736(93)90277-n
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发表时间：
1993-02-27
期刊：
影响因子：
168.9
通讯作者：
BOHUON, C
中科院分区：
文献类型：
--
作者：
ASSICOT, M;GENDREL, D;BOHUON, C
在患有各种甲状腺外疾病的患者的血液中发现了高浓度的降钙素样免疫反应性。通过降钙素前体的单克隆免疫放射测定，我们测量了各种细菌和病毒感染患者的血清降钙素原浓度。对医院疑似感染的 79 名儿童（新生儿至 12 岁）进行了前瞻性调查。 19 名患有严重细菌感染的患者在诊断时血清降钙素原浓度非常高（范围为 6-53 ng/mL），而 21 名儿童没有发现感染迹象（基线浓度 < 0.1 ng/mL）。抗生素治疗期间血清降钙素原值迅速下降。 11 名患有外周细菌定植或局部感染（无侵袭性败血症）的患者和 21 名病毒感染患者中的 18 名（86%）的浓度在正常范围内（0.1-1.5 ng/mL）或略高于正常范围（0.1-1.5 ng/mL）。在重症监护病房研究的 9 名严重烧伤患者中，降钙素原浓度（范围 0.1-120 ng/mL）的创伤后过程与感染并发症和急性脓毒症发作密切相关。无论降钙素原浓度如何，所有受试者的成熟降钙素浓度均正常。在脓毒症条件下，免疫学上与降钙素原相同的物质的浓度会升高。血清浓度似乎与微生物入侵的严重程度相关。
High concentrations of calcitonin-like immunoreactivity have been found in the blood of patients with various extrathyroid diseases. By means of a monoclonal immunoradiometric assay for calcitonin precursors, we have measured serum concentrations of procalcitonin in patients with various bacterial and viral infections.79 children (newborn to age 12 years) in hospital with suspected infections were investigated prospectively. 19 patients with severe bacterial infections had very high serum concentrations of procalcitonin at diagnosis (range 6-53 ng/mL) in comparison with 21 children found to have no signs of infection (baseline concentrations < 0.1 ng/m L). Serum procalcitonin values decreased rapidly during antibiotic therapy. 11 patients with peripheral bacterial colonisation or local infections without invasive sepsis and 18 (86%) of 21 patients with viral infections had concentrations within or slightly above the normal range (0.1-1.5 ng/mL). Among 9 severely burned patients studied in an intensive care unit, the post-traumatic course of procalcitonin concentrations (range 0.1-120 ng/mL) was closely related to infectious complications and acute septic episodes. Concentrations of mature calcitonin were normal in all subjects, whatever procalcitonin concentrations were found.Concentrations of a substance immunologically identical to procalcitonin are raised during septic conditions. Serum concentrations seem to be correlated with the severity of microbial invasion.