Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors
Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors
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成体结缔组织驻留的肥大细胞起源于晚期红髓系祖细胞
DOI：
10.1016/j.immuni.2018.09.023
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发表时间：
2018-10-16
期刊：
影响因子：
32.4
通讯作者：
Cao, Xuetao
中科院分区：
文献类型：
--
作者：
Li, Zhiqing;Liu, Shuxun;Cao, Xuetao
组织驻留肥大细胞与许多炎症和生理过程相关。尽管肥大细胞起源于卵黄囊，但成年肥大细胞的确切个体发育仍不清楚。在这里，我们使用命运图谱系统研究了肥大细胞的造血起源。我们已经证明，早期红骨髓祖细胞（EMP）、晚期EMP和定型造血干细胞（HSC）均通过中间整合素β7（+）祖细胞连续产生肥大细胞。从胚胎发生晚期到成体，除脂肪和胸膜腔外的大多数结缔组织中，早期EMP衍生的肥大细胞大部分被晚期EMP衍生的细胞所取代。因此，具有不同起源的肥大细胞表现出组织位置偏好：早期EMP衍生细胞仅限于脂肪和胸膜腔，晚期EMP衍生细胞主导大多数结缔组织，而HSC衍生细胞是粘膜中的主要群体。因此，胚胎起源塑造了成年肥大细胞的异质性，在免疫和发育方面具有不同的功能。
Tissue-resident mast cells are associated with many inflammatory and physiological processes. Although mast cells arise from the yolk sac, the exact ontogeny of adult mast cells remains unclear. Here we have investigated the hematopoietic origin of mast cells using fate-mapping systems. We have shown that early erythro-myeloid progenitors (EMPs), late EMPs, and definitive hematopoietic stem cells (HSCs) each gave rise to mast cells in succession via an intermediate integrin beta 7(+) progenitor. From late embryogenesis to adult, early EMP-derived mast cells were largely replaced by late EMP-derived cells in most connective tissues except adipose and pleural cavity. Thus, mast cells with distinct origin displayed tissue-location preferences: early EMP-derived cells were limited to adipose and pleural cavity and late EMP-derived cells dominated most connective tissues, while HSC-derived cells were a main group in mucosa. Therefore, embryonic origin shapes the heterogeneity of adult mast cells, with diverse functions in immunity and development.