2 SENSITIVE PERIODS FOR THE AMNESIC EFFECT OF ANISOMYCIN
2 SENSITIVE PERIODS FOR THE AMNESIC EFFECT OF ANISOMYCIN
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DOI：
10.1016/0091-3057(80)90145-8
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发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
MATTHIES, H
中科院分区：
文献类型：
--
作者：
GRECKSCH, G;MATTHIES, H
当在训练前10分钟和训练后80分钟或训练后240分钟和360分钟注射茴香霉素（80 μ g双侧注射到两个腰肌中）时，获得了对大鼠亮度辨别力保持的损害。在训练后45和165分钟注射茴香霉素时，未观察到健忘症。抑制剂的遗忘效应的两个独立的敏感期明显对应于同一学习过程巩固期间蛋白质合成增加的两个阶段。支持2个独立的和性质不同的大分子过程。抑制蛋白质合成作为茴香霉素遗忘作用的一个重要机制存在争议。
Impairment of retention of a brightness discrimination in rats was obtained when anisomycin (80 .mu.g bilaterally into both hippocampi) was injected 10 min before and 80 min after training or 240 and 360 min after training. No amnesia was observed when anisomycin was injected 45 and 165 min post training. The 2 separate sensitive periods for the amnesic effect of the inhibitor obviously correspond to the 2 phases of increased protein synthesis during the consolidation of the same learning procedure. The 2 independent and qualitatively different macromolecular processes were supported. The inhibition of protein synthesis as an important mechanism in the amnesic effect of anisomycin is debated.