Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC
Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC
复制标题
DOI：
10.1007/s00428-011-1103-0
复制
发表时间：
2011-08-01
期刊：
影响因子：
3.5
通讯作者：
Ocker, Matthias
中科院分区：
文献类型：
--
作者：
Quint, Karl;Agaimy, Abbas;Ocker, Matthias
组蛋白脱乙酰酶（HDAC）负责通过染色质重塑和控制肿瘤抑制基因来转录控制基因。在几种肿瘤中，它们的表达与临床病理因素和患者生存有关。本研究探讨了HDAC 1、2、3和7在肝细胞癌（HCC）中的表达及其与临床数据和患者生存率的相关性。组织微阵列170手术切除的原发性肝癌和相邻的未涉及的组织进行了评估，免疫组化的HDACs 1，2，3，7和Ki-67的表达，并分析了临床病理数据和患者的生存。与正常组织相比，HDAC 1、2、3和Ki-67在癌细胞中表达显著更高（HDAC 1：p = 0.034，HDAC 2和3和Ki-67：p < 0.001），而HDAC 7表达在HCC和非癌性肝组织之间没有差异。在肿瘤组织中，HDAC 1-3表达水平显示彼此、Ki-67和肿瘤分级的高度一致性（p < 0.001）。HDAC 2高表达与低级别和早期肿瘤的生存率差相关（p < 0.05）。HDAC 1、2和3（但不是HDAC 7）同工酶的表达与临床病理因素相关，HDAC 2表达对患者生存有影响。
Histone deacetylases (HDAC) are responsible for the transcriptional control of genes through chromatin remodeling and control tumor suppressor genes. In several tumors, their expression has been linked to clinicopathological factors and patient survival. This study investigates HDACs 1, 2, 3, and 7 expressions in hepatocellular carcinoma (HCC) and their correlation with clinical data and patient survival. Tissue microarrays of 170 surgically resected primary HCCs and adjacent uninvolved tissue were evaluated immunohistochemically for the expression of HDACs 1, 2, 3, 7, and Ki-67 and were analyzed with respect to clinicopathological data and patient survival. HDACs 1, 2, 3, and Ki-67 were expressed significantly higher in cancer cells compared to normal tissue (HDAC1: p = 0.034, HDACs 2 and 3 and Ki-67: p < 0.001), while HDAC7 expression did not differ between HCC and non-cancerous liver tissue. In tumor tissue HDACs 1-3 expression levels showed high concordance with each other, Ki-67 and tumor grade (p < 0.001). High HDAC2 expression was associated with poor survival in low-grade and early-stage tumors (p < 0.05). The expression of the HDACs 1, 2, and 3 (but not HDAC7) isoenzymes correlates with clinicopathological factors, and HDAC2 expression has an impact on patient survival.