Economic evaluation of vaccination programs: The impact of herd-immunity
Economic evaluation of vaccination programs: The impact of herd-immunity
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DOI：
10.1177/0272989x02239651
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发表时间：
2003-01-01
影响因子：
3.6
通讯作者：
Edmunds, WJ
中科院分区：
文献类型：
--
作者：
Brisson, M;Edmunds, WJ
疫苗接种的独特之处在于，它不仅降低了人源化动物的发病率，而且还间接保护未接种疫苗的动物免受感染（产生免疫力）。大部分疫苗接种计划的经济评估仍然使用无法考虑免疫接种产生的间接影响的模型。在这里，作者说明了在评估疫苗接种计划的成本效益时，纳入免疫外部性的重要性。为了做到这一点，他们比较了两种估计常规大规模疫苗接种益处的方法：一种是包括抗病毒免疫（动态方法），另一种是不包括抗病毒免疫（静态方法）。最后，他们使用的结果来澄清一些误解，是常见的文献中关于免疫力和模型产生的动态效应。
The unique characteristic of vaccination is that it not only reduces the incidence of disease in those humanized but also indirectly protects nonvaccinated susceptibles against infection (produces herd-immunity). The bulk of economic evaluations of vaccination programs continue to use models that cannot take into account the indirect effects produced by herd-immunity. Here, the authors illustrate the importance of incorporating herd-immunity externalities when assessing the cost-effectiveness of vaccination programs. To do this, they compare 2 methods of estimating the benefits of routine mass vaccination: one that includes herd-immunity (dynamic approach) and one that does not (static approach). Finally, they use the results to clarify a number of misconceptions that are common in the literature concerning herd-immunity and dynamical effects produced by models.