Locomotion and eye behaviour under controlled environment in individuals with Alzheimer's disease.
Locomotion and eye behaviour under controlled environment in individuals with Alzheimer's disease.
复制标题
阿尔茨海默病患者在受控环境下的运动和眼睛行为。
DOI：
10.1109/embc.2015.7319904
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Suzuki T
中科院分区：
文献类型：
--
作者：
Suzuki T
这项研究的目的是在模拟的真实世界环境中检测患有后部皮质萎缩(PCA)和典型阿尔茨海默病(TAD)的个体的简单运动和眼睛行为。后部皮质萎缩(PCA)是一种神经退行性疾病，其特征是顶叶、枕骨和枕颞部组织丢失，高级视觉功能进行性损害，而记忆和语言相对较少。目标运动类型是在一系列走廊中行走，上下楼梯，以及在有或没有障碍物的情况下穿过开放房间。实验中使用眼动测量和惯性矩单位(IMU)，提取左脚的合成加速度和注视时间。来自三名参与者的研究结果以病例系列的形式呈现：一名对照，一名PCA和一名TAD患者。在所有类型的运动中，PCA患者的平均合成加速度是最慢的，尤其是在楼梯上。PCA和TAD参与者的平均合成加速度比对照组参与者慢。PCA参与者的平均注视持续时间比TAD和对照组参与者长，然而，TAD和对照组参与者的平均注视持续时间相似。结果可能有助于描述PCA和TAD的运动和眼睛行为，并可能提出支持有效诊断和评估疾病进展的方法。
This study aimed to examine simple locomotion and eye behaviour of individuals with Posterior Cortical Atrophy (PCA) and typical Alzheimer's disease (tAD) within a simulated real-world environment. Posterior cortical atrophy (PCA) is a neurodegenerative condition characterised by parietal, occipital and occipito-temporal tissue loss and progressive impairment of higher-order visual function in contrast to relatively spared memory and language. Targeted types of locomotion were walking in a series of corridors, up or down stairs, and across an open room with or without the presence of an obstacle. Eye tracking measures and inertial moment units (IMU) were used in this experiment, and resultant acceleration of left foot and fixation duration were extracted. Findings from three participants are presented as a case series: one control, one PCA and one tAD patient. The averaged resultant acceleration of PCA patient was the slowest in all types of locomotion, especially in stairs. The averaged resultant accelerations of PCA and tAD participants were slower than the control participant. The PCA participant had longer mean fixation durations than the tAD and control participants, however, mean fixation duration was similar between tAD and control participants. Results may help characterise locomotion and eye behaviour in PCA and tAD and may suggest ways to support effective diagnosis and assessment of disease progression.