A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging
A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging
复制标题
蜂蜜碳纳米粒子的绿色合成及其在实时光声成像中的应用
DOI：
10.1007/s12274-013-0308-8
复制
发表时间：
2013-05-01
期刊：
影响因子：
9.9
通讯作者：
Pan, Dipanjan
中科院分区：
文献类型：
--
作者：
Wu, Lina;Cai, Xin;Pan, Dipanjan
前哨淋巴结（SLN）成像可以为我们提供有关癌症疾病进展的关键信息。实时高分辨率术中光声成像（PAI）结合近红外（NIR）探头可以提供直接识别和切除SLN或收集组织样本的即时成像机会。在这项工作中，一个商业上可行的合成方法，揭示了制造发光碳纳米粒子与快速清除性能。追求一锅法"绿色"技术，其涉及用有机大分子（例如，聚山梨醇酯、聚乙二醇）。有趣的是，裸碳纳米颗粒首次来自商业食品级蜂蜜。表面涂覆的颗粒明显小于（约7nm）比以前探索的颗粒（金，单壁碳纳米管，铜）的SLN成像。结果表明SLN的信号增强异常迅速（102 min）。由于其在NIR区域的强光学吸收、微小尺寸和快速淋巴运输，该平台为更快切除SLN提供了巨大潜力，并且可以降低由于染料或低分辨率成像技术的错误标记而在腋窝检查中引起的并发症。
Imaging sentinel lymph nodes (SLN) could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intraoperative photoacoustic imaging (PAI) in conjunction with a near-infrared (NIR) probe may offer opportunities for the immediate imaging for direct identification and resection of SLN or collecting tissue samples. In this work a commercially amenable synthetic methodology is revealed for fabricating luminescent carbon nanoparticles with rapid clearance properties. A one-pot “green” technique is pursued, which involved rapid surface passivation of carbon nanoparticles with organic macromolecules (e.g., polysorbate, polyethyleneglycol) in solvent-free conditions. Interestingly, the naked carbon nanoparticles are derived for the first time, from commercial food grade honey. Surface coated particles are markedly smaller (∼7 nm) than previously explored particles (gold, single-walled carbon nanotubes, copper) for SLN imaging. The results indicate an exceptionally rapid signal enhancement (∼2 min) of the SLN. Owing to their strong optical absorption in the NIR region, tiny size and rapid lymphatic transport, this platform offers great potential for faster resection of SLN and may lower complications caused in axillary investigation by mismarking with dyes or low-resolution imaging techniques.