Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping.
Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping.
复制标题
通过定量磁敏感图测量帕金森病中铁的区域渐进积累
DOI：
10.1002/nbm.3489
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发表时间：
2017-04
影响因子：
2.9
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Guan X;Xuan M;Gu Q;Huang P;Liu C;Wang N;Xu X;Luo W;Zhang M
帕金森病（PD）的进展似乎根据疾病阶段而变化，这极大地影响了PD患者的管理。然而，PD进展的潜在机制仍不清楚。本研究旨在探讨PD患者不同阶段铁蓄积的进展模式。招募了60名右利手PD患者和40名正常对照。根据疾病分期，将45例Hoehn-Yahr分期≤ 2.5和15例Hoehn-Yahr分期≥ 3的患者分别分为早期PD（EPD）和晚期PD（LPD）组。采用定量磁敏感性绘图（QSM）测量覆盖大脑、小脑和中脑的皮质下主要核团中的铁含量。EPD患者黑质黑质白质（SNc）的QSM值显著高于对照组。在LPD患者中，虽然与对照组和EPD患者相比，SNc继续显示QSM值增加，但显示QSM值增加的区域扩展到包括黑质网状部（SNr）、红核（RN）和苍白球（GP）。我们的数据还表明，铁沉积更显着的GP内段（GPi）比GP外段。其他区域的QSM值在各组中均无显著变化。因此，我们能够证实在PD的不同阶段铁积累的区域渐进模式，表明SNc中的铁沉积仅在疾病的早期阶段受到影响，而SNr，RN和GP，特别是GPi段，在疾病的晚期阶段参与。这是一项初步研究，提供了PD中铁相关进展的客观证据。版权所有© 2016约翰威利父子有限公司.
The progression of Parkinson's disease (PD) seems to vary according to the disease stage, which greatly influences the management of PD patients. However, the underlying mechanism of progression in PD remains unclear. This study was designed to explore the progressive pattern of iron accumulation at different stages in PD patients. Sixty right‐handed PD patients and 40 normal controls were recruited. According to the disease stage, 45 patients with Hoehn–Yahr stage ≤ 2.5 and 15 patients with Hoehn–Yahr stage ≥ 3 were grouped into early‐stage PD (EPD) and late‐stage PD (LPD) groups, respectively. The iron content in the cardinal subcortical nuclei covering the cerebrum, cerebellum and midbrain was measured using quantitative susceptibility mapping (QSM). The substantia nigra pars compacta (SNc) showed significantly increased QSM values in the EPD patients compared with the controls. In the LPD patients, while the SNc continued to show increased QSM values compared with the controls and EPD patients, the regions showing increased QSM values spread to include the substantia nigra pars reticulata (SNr), red nucleus (RN) and globus pallidus (GP). Our data also indicated that iron deposition was more significant in the GP internal segment (GPi) than in the GP external segment. No other regions showed significant changes in QSM values among the groups. Therefore, we were able to confirm a regionally progressive pattern of iron accumulation in the different stages of PD, indicating that iron deposition in the SNc is affected exclusively in the early stages of the disease, while the SNr, RN and GP, and particularly the GPi segment, become involved in advanced stages of the disease. This is a preliminary study providing objective evidence of the iron‐related progression in PD. Copyright © 2016 John Wiley & Sons, Ltd.