Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome
Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome
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DOI：
10.1164/rccm.200206-542oc
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发表时间：
2003-03-01
影响因子：
24.7
通讯作者：
Weaver, LK
中科院分区：
文献类型：
--
作者：
Orme, J;Romney, JS;Weaver, LK
虽然急性呼吸窘迫综合征的生存率有所提高，但关于生存后的生活质量以及生活质量与肺功能之间的关系的信息有限。我们前瞻性地测量了急性呼吸窘迫综合征幸存者的肺功能、情绪功能和健康相关的生活质量，这些幸存者是从一项随机临床试验中招募的，该试验在患者康复后1年进行了高潮气量与低潮气量机械通气。高潮气量和低潮气量治疗的患者在任何肺功能指标上均无显著差异。两组中约80%的患者表现出弥散能力降低; 20%有气流阻塞，20%有胸部限制。抑郁和焦虑的测量分数在正常范围内，表明他们没有明显的情感症状。然而，两组都报告了身体功能、维持其角色的身体能力（角色-身体）、身体疼痛、一般健康和活力（能量）方面的健康相关生活质量下降，疾病影响特征问卷中报告了类似的身体限制。肺功能异常与反映身体功能的健康相关生活质量下降相关。急性呼吸窘迫综合征幸存者接受高潮气量和低潮气量治疗后肺功能异常，这与出院后一年健康相关生活质量下降有关。
Although survival rates for acute respiratory distress syndrome have increased, there is only limited information regarding the quality of life and the relationship between quality of life and pulmonary function after survival. We prospectively measured pulmonary function, emotional function, and health-related quality of life in a cohort of acute respiratory distress syndrome survivors recruited from patients who were enrolled in a randomized clinical trial of high versus low tidal volume mechanical ventilation at I year after their recovery. No significant differences were found between the patients treated with high and low tidal volumes on any pulmonary function measure. Approximately 80% of the patients in both groups demonstrated reduced diffusing capacity; 20% had airflow obstruction, and 20% had chest restriction. Scores on measures of depression and anxiety were within the normal ranges, suggesting that they did not have significant affective symptoms. However, both groups reported decreased health-related quality of life in physical functioning, physical ability to maintain their roles (role-physical), bodily pain, general health, and vitality (energy) on the Medical Outcome Study Short Form Health Survey with similar physical limitations reported on the Sickness Impact Profile questionnaire. The pulmonary function abnormalities correlated with decreased health-related quality of life for domains reflecting physical function. Acute respiratory distress syndrome survivors treated with high and low tidal volumes have abnormal pulmonary function that was related to decreased health-related quality of life I year after hospital discharge.