P53 IN ENDOMETRIAL CANCER AND ITS PUTATIVE PRECURSORS - EVIDENCE FOR DIVERSE PATHWAYS OF TUMORIGENESIS
P53 IN ENDOMETRIAL CANCER AND ITS PUTATIVE PRECURSORS - EVIDENCE FOR DIVERSE PATHWAYS OF TUMORIGENESIS
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DOI：
10.1016/0046-8177(95)90204-x
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发表时间：
1995-11-01
期刊：
影响因子：
3.3
通讯作者：
KURMAN, RJ
中科院分区：
文献类型：
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作者：
SHERMAN, ME;BUR, ME;KURMAN, RJ
为了阐明p53异常在子宫内膜肿瘤发生中的作用，采用常规免疫组化技术研究了一组不同的子宫内膜肿瘤及其假定的前体、子宫内膜不典型增生和子宫内膜上皮内癌（EIC）。28例浆液性癌中24例（86%）p53蛋白阳性，45例浆液性癌中9例（20%）p53蛋白阳性（P
To elucidate the role of p53 abnormalities in endometrial tumorigenesis, a diverse group of endometrial neoplasms and their putative precursors, atypical endometrial hyperplasia, and endometrial intraepithelial carcinoma (EIC) were studied using a conventional immunohistochemical technique. Immunostaining for p53 protein was detected in 24 (86%) of 28 serous carcinomas compared with nine (20%) of 45 endometrioid carcinomas (P