Effect of Human Seminal Plasma on the Lytic Activity of Natural Killer Cells and Presumptive Identification of Participant Macromolecules
Effect of Human Seminal Plasma on the Lytic Activity of Natural Killer Cells and Presumptive Identification of Participant Macromolecules
复制标题
人精浆对自然杀伤细胞裂解活性的影响及参与者大分子的推定鉴定
DOI：
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发表时间：
1990
影响因子：
3.6
通讯作者：
J. Polgár
中科院分区：
文献类型：
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作者：
R. Ablin;J. M. Bartkus;J. Polgár
摘要：使用自然杀伤（NK）细胞的裂解活性作为体外参数，人精浆（SeP1）和参与大分子的免疫调节特性进行了研究。SeP1和色谱可分离组分对NK细胞活性的显著抑制（P < 0.05）与高分子量和低分子量（Mr）大分子有关。SePl抑制在加热至56°C持续30分钟后保持，并且似乎在效应物而不是靶细胞的水平上起作用。高和低先生馏分的理化特性提供了推定鉴定的参与转氨酶和arylandins作为主要分子的贡献SeP1免疫抑制。
ABSTRACT: Using the lytic activity of natural killer (NK) cells as an in vitro parameter, the immunoregulatory properties of human seminal plasma (SeP1) and participant macromolecules have been investigated. Significant (P < 0.05) suppression of NK cell activity by SeP1 and chromatographically separable fractions was demonstrated in association with high and low molecular weight (Mr) macromolecules. SePl suppression was retained after heating to 56°C for 30 min, and appeared to function at the level of the effector, rather than target cell. Physicochemical characterization of high and low Mr fractions provided presumptive identification of the participation of transglutaminase and prostaglandins as the principal molecules contributory to SeP1 immunosuppression.
NK 和 T 细胞亚群调节人体内抗原诱导的淋巴母细胞 B 细胞的抗体产生。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brieva,JA;Targan,S;Stevens,RH
通讯作者：
Stevens,RH