Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
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DOI：
10.1016/j.archoralbio.2010.11.022
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发表时间：
2011-08-01
影响因子：
3
通讯作者：
Freitas, Roseana de Almeida
中科院分区：
文献类型：
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作者：
Lobao Veras Barros, Simone Souza;Gomes Henriques, Aguida Cristina;Freitas, Roseana de Almeida
目的：为探讨MMP-1、MMP-2、MMP-7、MMP-9和MMP-26在口腔鳞状细胞癌（SCC）中的表达与肿瘤部位和组织学分级的关系，选择15例下唇SCC和15例舌SCC，分为低度恶性组（n = 17）和高度恶性组（n = 13）。MMPs在舌鳞癌中的表达明显高于癌细胞，其中MMP-9的表达差异有统计学意义（P < 0.05）。MMP-7、MMP-26在高级别SCC中的表达差异有统计学意义（P <0.05）。MMP-7和MMP-26的表达与口腔鳞癌的恶性程度呈正相关。结论：MMP-7和MMP-26的表达与口腔鳞癌的恶性程度呈正相关，MMP-26的表达与口腔鳞癌的恶性程度呈正相关。(C)2011爱思唯尔有限公司版权所有。
Objective: To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy.Study design: Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13).Results: Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26.Conclusion: The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue. (C) 2011 Elsevier Ltd. All rights reserved.