Evolutionary genomics of Culex pipiens: global and local adaptations associated with climate, life-history traits and anthropogenic factors.
Evolutionary genomics of Culex pipiens: global and local adaptations associated with climate, life-history traits and anthropogenic factors.
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DOI：
10.1098/rspb.2015.0728
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发表时间：
2015-07-07
期刊：
影响因子：
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通讯作者：
Nuzhdin SV
中科院分区：
文献类型：
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作者：
Asgharian H;Chang PL;Lysenkov S;Scobeyeva VA;Reisen WK;Nuzhdin SV
我们提出了第一个全基因组的研究，最近在库蚊物种复杂的进化，重点是基因组的程度，功能的目标和可能的原因，全球和本地的适应。我们对6个C. pipiens和两个种群的外群库蚊torrentium。我们使用主成分分析来系统地研究种群间的差异自然选择，并开发了一种系统发育扫描方法来分析没有单倍型数据的混合物。我们发现了地理分布在塑造种群结构和指定基因组选择模式方面的突出作用的证据。多个适应性事件，涉及基因牵连的自生，滞育和杀虫剂抗性仅限于特定的人群。我们估计，在每个群体中，大约5-20%的基因（包括几个组蛋白基因）和几乎一半的注释途径正在进行选择性扫描。在非基因区域和染色质重塑基因中扫描的高发生率表明基因表达变化的适应性重要性。我们假设，全球适应过程中的C。pipiens复合体可能与南向北的范围扩张有关，需要调整染色质构象。强大的本地签名的适应和出现的混合桥载体，有必要在指定控制剂的群体的基因组评估。
We present the first genome-wide study of recent evolution in Culex pipiens species complex focusing on the genomic extent, functional targets and likely causes of global and local adaptations. We resequenced pooled samples of six populations of C. pipiens and two populations of the outgroup Culex torrentium. We used principal component analysis to systematically study differential natural selection across populations and developed a phylogenetic scanning method to analyse admixture without haplotype data. We found evidence for the prominent role of geographical distribution in shaping population structure and specifying patterns of genomic selection. Multiple adaptive events, involving genes implicated with autogeny, diapause and insecticide resistance were limited to specific populations. We estimate that about 5–20% of the genes (including several histone genes) and almost half of the annotated pathways were undergoing selective sweeps in each population. The high occurrence of sweeps in non-genic regions and in chromatin remodelling genes indicated the adaptive importance of gene expression changes. We hypothesize that global adaptive processes in the C. pipiens complex are potentially associated with South to North range expansion, requiring adjustments in chromatin conformation. Strong local signature of adaptation and emergence of hybrid bridge vectors necessitate genomic assessment of populations before specifying control agents.