Mild behavioral impairment as a predictor of cognitive functioning in older adults.
Mild behavioral impairment as a predictor of cognitive functioning in older adults.
复制标题
轻度行为障碍作为老年人认知功能的预测因子。
DOI：
10.1017/s1041610220000678
复制
发表时间：
2021
影响因子：
7
通讯作者：
Potter,Huntington
中科院分区：
文献类型：
--
作者：
Rouse,HillaryJ;Small,BrentJ;Schinka,JohnA;Loewenstein,DavidA;Duara,Ranjan;Potter,Huntington
目的探讨轻度行为障碍（MBI）对认知健康或轻度认知障碍（MCI）老年人认知能力的影响。方法对来自佛罗里达阿尔茨海默病研究中心的老年人样本（n = 497）进行二级数据分析，这些老年人要么认知健康（n = 285），要么被诊断为轻度认知障碍（n = 212）。超过一半的样本（n = 255）符合MBI的可操作诊断标准。执行功能、注意力、短期记忆和情景记忆的认知领域使用一系列神经心理学测试进行评估。结果与非MBI患者相比，MBI患者在执行功能、注意力和情景记忆方面表现较差。一项重要的相互作用表明，与只有MCI的人相比，MBI和MCI患者在情景记忆任务中的表现更差，但在认知健康的老年人中，有或没有MBI的人在这一认知领域的表现没有显著差异。正如预期的那样，认知健康的老年人在每个认知领域都比轻度认知障碍患者表现得更好。结论：本研究发现证据表明，与认知状态无关，MBI患者在执行功能、注意力和情景记忆测试中的表现比非MBI患者差。此外，那些患有轻度认知障碍和轻度认知障碍的人在情景记忆任务中的表现明显比只有轻度认知障碍的人差。这些结果为与MBI相关的独特认知表型提供了支持，并强调了评估认知和行为症状的必要性。
ObjectiveTo assess the influence of mild behavioral impairment (MBI) on the cognitive performance of older adults who are cognitively healthy or have mild cognitive impairment (MCI).MethodsSecondary data analysis of a sample (n = 497) of older adults from the Florida Alzheimer’s Disease Research Center who were either cognitively healthy (n = 285) or diagnosed with MCI (n = 212). Over half of the sample (n = 255) met the operationalized diagnostic criteria for MBI. Cognitive domains of executive function, attention, short-term memory, and episodic memory were assessed using a battery of neuropsychological tests.ResultsOlder adults with MBI performed worse on tasks of executive function, attention, and episodic memory compared to those without MBI. A significant interaction revealed that persons with MBI and MCI performed worse on tasks of episodic memory compared to individuals with only MCI, but no significant differences were found in performance in cognitively healthy older adults with or without MBI on this cognitive domain. As expected, cognitively healthy older adults performed better than individuals with MCI on every domain of cognition.ConclusionsThe present study found evidence that independent of cognitive status, individuals with MBI performed worse on tests of executive function, attention, and episodic memory than individuals without MBI. Additionally, those with MCI and MBI perform significantly worse on episodic memory tasks than individuals with only MCI. These results provide support for a unique cognitive phenotype associated with MBI and highlight the necessity for assessing both cognitive and behavioral symptoms.