Insights Into the Role of Ubiquitination in Meiosis: Fertility, Adaptation and Plant Breeding.
Insights Into the Role of Ubiquitination in Meiosis: Fertility, Adaptation and Plant Breeding.
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深入了解泛素化在减数分裂中的作用：生育力、适应和植物育种。
DOI：
10.1199/tab.0187
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Wang, Yingxiang
中科院分区：
文献类型：
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作者：
Bolanos-Villegas, Pablo;Xu, Wanyue;Wang, Yingxiang
泛素化是一种翻译后修饰过程，在真核细胞分裂包括减数分裂的蛋白质降解中起着核心作用。这种修饰通过其多效性修饰许多蛋白质的能力在全球范围内影响不同的细胞过程。减数分裂在有性生殖中是必不可少的，它包括两轮核分裂，随后一轮DNA复制产生单倍体配子。与有丝分裂不同，减数分裂有一个独特的前期I，涉及同源染色体的相互作用，包括配对、突触、重组和分离。在过去的几十年里，分子遗传学研究已经确定了许多参与减数分裂过程的蛋白质。本文综述了泛素化在植物减数分裂细胞周期进程和重组中的作用，特别是后期促进复合物和E3连接酶在调节交叉形成中的作用及其对植物进化和育种的影响。
Ubiquitination is a post-translational modification process that plays a central role in protein degradation in eukaryotic cell cell division, including meiosis. This modification affects different cellular processes on a global scale by its pleiotropic ability to modify numerous proteins. Meiosis is essential for sexual reproduction and involves two rounds of nuclear division following a single round of DNA replication to produce haploid gametes. Unlike mitosis, meiosis has a unique prophase I, which involves homologous chromosome interaction including pairing, synapsis, recombination and segregation. Over the last several decades, molecular genetic studies have identified many proteins that participate in meiotic progression. In this review, we focus on the recent advances regarding the role of ubiquitination during plant meiotic cell cycle progression and recombination, especially the role played by the Anaphase-Promoting Complex and E3 ligases in modulating crossover formation and its impact on evolution and plant breeding.