Biomarkers of endothelial activation/dysfunction in infectious diseases.
Biomarkers of endothelial activation/dysfunction in infectious diseases.
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DOI：
10.4161/viru.24530
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发表时间：
2013-08-15
期刊：
影响因子：
5.2
通讯作者：
Liles WC
中科院分区：
文献类型：
--
作者：
Page AV;Liles WC
内皮功能障碍导致多种潜在严重的传染病和综合征的发病机制，包括败血症和感染性休克、溶血性尿毒症综合征、严重疟疾和登革出血热。由于内皮活化通常先于明显的内皮功能障碍，因此血清和/或血浆中活化内皮的生物标志物可以在经典识别的疾病标志物之前被检测到，因此，在临床上可用作全身感染性疾病中疾病严重程度或预后的生物标志物。在这篇综述中，讨论了内皮细胞功能介质（血管生成素-1和-2）、凝血途径成分（血管性血友病因子、ADAMTS13和血栓调节蛋白）、可溶性细胞表面粘附分子（可溶性E-选择素、sICAM-1和sVCAM-1）以及血管张力和通透性调节因子（VEGF和sFlt-1）作为严重感染性疾病生物标志物的现状在败血症、大肠杆菌 O157:H7 感染、疟疾和登革热病毒感染的情况下。
Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic syndrome, severe malaria, and dengue hemorrhagic fever. Because endothelial activation often precedes overt endothelial dysfunction, biomarkers of the activated endothelium in serum and/or plasma may be detectable before classically recognized markers of disease, and therefore, may be clinically useful as biomarkers of disease severity or prognosis in systemic infectious diseases. In this review, the current status of mediators of endothelial cell function (angiopoietins-1 and -2), components of the coagulation pathway (von Willebrand Factor, ADAMTS13, and thrombomodulin), soluble cell-surface adhesion molecules (soluble E-selectin, sICAM-1, and sVCAM-1), and regulators of vascular tone and permeability (VEGF and sFlt-1) as biomarkers in severe infectious diseases is discussed in the context of sepsis, E. coli O157:H7 infection, malaria, and dengue virus infection.