Long-term control or possible cure? Treatment of stage D2 prostate cancer under chemotherapy using cisplatin and estramustine phosphate followed by maximal androgen blockade
Long-term control or possible cure? Treatment of stage D2 prostate cancer under chemotherapy using cisplatin and estramustine phosphate followed by maximal androgen blockade
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长期控制还是可能治愈？
DOI：
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发表时间：
2007
影响因子：
2
通讯作者：
M. Igawa
中科院分区：
文献类型：
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作者：
S. Urakami;H. Shiina;M. Sumura;S. Honda;K. Wake;T. Hiraoka;S. Inoue;N. Ishikawa;M. Igawa
转移性前列腺癌（PC）是无法治愈的雄激素剥夺治疗单独，由于雄激素非依赖性/超敏感细胞的存在，在未经治疗的PC。一名67岁男性被诊断为PC（Gleason评分，5 + 4）伴多发性骨转移。他接受了顺铂和磷酸雌莫司汀（EMP）的化学激素治疗，随后接受了最大雄激素阻断，并显示出完全缓解。截至撰写本文时，尽管停止治疗，但15年以上未观察到临床或前列腺特异性抗原复发。这是第一份报告，以表明一个可能的治愈转移性PC的化疗激素治疗结合适当的抗肿瘤药物靶向雄激素非依赖性和依赖性克隆之前的难治性状态。
Metastatic prostate cancer (PC) is incurable by androgen deprivation therapy alone, due to the presence of androgen-independent/supersensitive cells in hormone-naïve PC. A 67-year-old man was diagnosed with PC (Gleason score, 5 + 4) with multiple bone metastases. He was treated by chemohormonal therapy with cisplatin and estramustine phosphate (EMP) followed by maximal androgen blockade, and showed a complete response. As of the time of writing, no clinical or prostate-specific antigen recurrence has been observed for over 15 years, despite cessation of the treatment. This is the first report to indicate a possible cure of metastatic PC by chemohormonal therapy combined with appropriate anti-tumor drugs targeted to both androgen-independent and -dependent clones before the hormone-refractory state.
大鼠体内肿瘤大小与化疗激素联合治疗前列腺癌治愈率之间的关系。
影响因子：
11.2
作者：
Isaacs,JT
通讯作者：
Isaacs,JT