Resolution-Recovery for EPR Imaging of Free Radical Molecules in Mice
Resolution-Recovery for EPR Imaging of Free Radical Molecules in Mice
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DOI：
10.1002/mrm.22029
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Hirata, Hiroshi
中科院分区：
文献类型：
--
作者：
Ikebata, Yusuke;Sato-Akaba, Hideo;Hirata, Hiroshi
本文报道了一种提高连续波电子顺磁共振（CW-EPR）成像中自由基分子分布图像分辨率的后处理方法。EPR成像的分辨率恢复方法克服了EPR成像空间分辨率低的问题，给生物医学应用带来了困难。用这种方法获得了弛豫时间很短的自由基分子分布的高空间分辨率图像。该方法的两步后处理包括常规反褶积和滤波反投影以及迭代反褶积过程。分辨率恢复方法证明了与稳定的硝酰基自由基在小鼠头部的三维（3D）成像。在幻影实验与解决方案的三芳基甲基（TAM）自由基，空间分辨率提高了7倍的分辨率恢复方法。Magn Reson Med 62：788-795，2009. (C)2009 Wiley-Liss，Inc.
A method of post-processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous-wave electron paramagnetic resonance (CW-EPR) Imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution-recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two-step postprocessing consists of conventional deconvolution and filtered back-projection and a process of iterative deconvolution. The resolution-recovery method was demonstrated with three-dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution-recovery method. Magn Reson Med 62:788-795, 2009. (C) 2009 Wiley-Liss, Inc.