Hard tissue formation induced by synthetic oligopeptide derived from an enamel matrix derivative
Hard tissue formation induced by synthetic oligopeptide derived from an enamel matrix derivative
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由牙釉质基质衍生物衍生的合成寡肽诱导硬组织形成
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
M. Ueda
中科院分区：
文献类型：
--
作者：
M. Noguchi;K. Tominaga;A. Tanaka;M. Ueda
背景资料：嗜酸性粒细胞圆体（ERB）是由不同长度的氨基酸序列组成，代表釉原蛋白基因外显子5的一部分。先前已显示ERB在皮下注射产品Emdogain®的大鼠背部积聚。在本研究中，人工合成具有与该部分相似的氨基酸序列的寡肽，并检查其效果。方法：将多肽溶液应用于大鼠上颌骨牙周缺损模型。在实验开始后7天和14天，对这些组织的切片进行组织病理学和组织化学检查。结果如下：实验组暴露牙本质表面形成硬组织，骨桥蛋白和I型胶原（COLI）均位于硬组织周围。硬组织的PAS染色比牙本质深，COLI阳性的纤维垂直插入新形成的硬组织的边缘。对照组未见硬组织形成。结论：人工合成的寡肽可以诱导小鼠脑内神经元凋亡，
Background: Eosinophilic round bodies (ERBs) are composed of fragments of amino acid sequences of varying lengths, which represent a portion of exon 5 of amelogenin gene. ERBs have previously been shown to accumulate in the backs of rats subcutaneously injected with the product Emdogain®. In the present study, an oligopeptide with an amino acid sequence similar to this portion was artificially synthesized, and its effects were examined. Methods: The peptide solution was applied to periodontal defects created on the maxillae of rats. Sections from these tissues were histopathologically and immunohistochemically examined at 7 and 14 days after the start of the experiment. Results: In the experimental group, hard tissue had formed on the surface of exposed dentin, and both osteopontin and collagen type I (COLI) were localized around the hard tissue. The hard tissue was stained with periodic acid-Schiff (PAS) more deeply than was the dentin, and the fibers that were positive for COLI were vertically inserted in the rim of the newly-formed hard tissue. No hard tissue formation was found in the control group. Conclusion: These results suggest that synthetic oligopeptide administration can induc
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影响因子：
4.1
作者：
DErrico, JA;Macneil, RL;Somerman, MJ
通讯作者：
Somerman, MJ
影响因子：
3
作者：
R. Lamont MacNeil;J. Berry;C. Strayhorn;M. Somerman
通讯作者：
R. Lamont MacNeil;J. Berry;C. Strayhorn;M. Somerman
影响因子：
2.9
作者：
Cheng, H;Caterson, B;Yamauchi, M
通讯作者：
Yamauchi, M
影响因子：
4.1
作者：
D'Errico, JA;Ouyang, H;Somerman, MJ
通讯作者：
Somerman, MJ