IDENTIFICATION OF A GENE, MLL, THAT SPANS THE BREAKPOINT IN 11Q23 TRANSLOCATIONS ASSOCIATED WITH HUMAN LEUKEMIAS
IDENTIFICATION OF A GENE, MLL, THAT SPANS THE BREAKPOINT IN 11Q23 TRANSLOCATIONS ASSOCIATED WITH HUMAN LEUKEMIAS
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DOI：
10.1073/pnas.88.23.10735
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发表时间：
1991-12-01
影响因子：
11.1
通讯作者：
DIAZ, MO
中科院分区：
文献类型：
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作者：
ZIEMINVANDERPOEL, S;MCCABE, NR;DIAZ, MO
复发性染色体易位涉及11号染色体q23带，在急性淋巴性白血病，特别是急性髓性白血病中被观察到。我们最近发现，4个11q23易位的断点t(4;11)（q21;q23）、t(6;11)（q27;q23）、t(9;11)（p22;q23）和t(11;19)（q23;p13.3）包含在一个酵母人工染色体克隆中，该克隆携带CD3D和CD3G基因位点。我们已经在CD3酵母人工染色体中发现了一个跨越4的断点连接的转录单元；11、9;11，和11；19个易位，我们描述了另外两个在RS4中上调的相关转录本；11细胞系。我们将这种基因命名为MLL（髓/淋巴，或混合谱系，白血病）。
Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia).