Direct vasoactive intestinal polypeptide-containing projection from the suprachiasmatic nucleus to spinal projecting hypothalamic paraventricular neurons
Direct vasoactive intestinal polypeptide-containing projection from the suprachiasmatic nucleus to spinal projecting hypothalamic paraventricular neurons
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含有从视交叉上核到脊髓投射的下丘脑室旁神经元的直接血管活性肠多肽投射
DOI：
10.1016/s0006-8993(96)01246-2
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
R. Buijs
中科院分区：
文献类型：
--
作者：
Rebecca Teclemariam;A. Kalsbeek;P. Pévet;R. Buijs
在哺乳动物中，光周期信息通过多突触通路从视网膜传递到松果体，所述多突触通路包括视交叉上核（SCN）、下丘脑室旁核（PVN）、脊髓节前神经元以及最后的上级颈神经节。缺乏关于PVN中的站点或SCN发射机参与该途径中的信息传输的精确数据。在本实验中，我们调查是否SCN传出含有血管活性肠多肽（VIP）支配PVN神经元的项目，脊髓。结合逆行追踪和免疫细胞化学与共聚焦激光扫描显微镜的帮助下，使我们能够评估可能的相互作用的SCN传出神经和脊髓投射神经元的PVN。大约30%的自主神经投射神经元的背侧PVN和40%的腹侧PVN接受VIP神经支配，主要是在他们的树突。这些结果为SCN衍生的VIP参与向松果体传递昼夜节律信息提供了进一步的证据。
In mammals, photoperiodic information is conveyed from the retina to the pineal through a polysynaptic pathway, which includes the suprachiasmatic nucleus (SCN), the paraventricular nucleus of the hypothalamus (PVN), the spinal preganglionic neurons and, finally, the superior cervical ganglion. Precise data on the site in the PVN or which SCN transmitters are involved in the transmission of information in this pathway is lacking. In the present experiment we investigated whether SCN efferents containing vasoactive intestinal polypeptide (VIP) innervate PVN neurons that project to the spinal cord. A combination of retrograde tracing and immunocytochemistry with the aid of a confocal laser scanning microscope allowed us to assess possible interaction of SCN efferents and spinal cord projecting neurons in the PVN. Approximately 30% of identified autonomic projecting neurons in the dorsal PVN and 40% in the ventral PVN received VIP innervation mainly on their dendrites. These results provide further evidence for the involvement of SCN-derived VIP in the transmission of circadian information to the pineal.
DOI：
10.1073/pnas.87.3.933
发表时间：
1990-02-01
影响因子：
11.1
作者：
CROPPER, EC;PRICE, D;WEISS, KR
通讯作者：
WEISS, KR