The gamma2 chain of laminin-5 as an indicator of increased risk for recurrence in T1 stage tongue cancer.
The gamma2 chain of laminin-5 as an indicator of increased risk for recurrence in T1 stage tongue cancer.
复制标题
层粘连蛋白 5 的 γ2 链作为 T1 期舌癌复发风险增加的指标。
作者：
P. Stoltzfus;A. Högmo;J. Lindholm;U. Aspenblad;G. Auer;E. Munck
背景
局部小舌癌的治疗是在充分广泛的手术和/或放射治疗以确保安全治愈和将与治疗相关的发病率降至最低之间的平衡行动。这些癌症的生物学侵袭性是可变的，传统的组织病理学没有提供关于局部或区域复发风险的足够信息。层粘连蛋白-5是一种细胞外基质蛋白，对上皮细胞的侵袭具有特殊的重要性。
患者和方法
我们调查了43例T1舌癌患者的诊断活检标本，这些标本仅接受楔形切除治疗。使用抗层粘连蛋白-5的Gamma2链的多克隆抗体进行免疫组织化学分析。
结果
对36个样本进行了评估，16名患者复发。大多数有肿瘤复发的患者(75%)有50%或更多的染色模式，而没有复发的患者(45%)较少。
结论
为了优化对个体T1舌癌患者的治疗，抗层粘连蛋白-5的免疫染色似乎是一种可能的有用工具。
BACKGROUND
Treatment of small, localized tongue cancer is an act of balance between sufficiently extensive surgery and/or radiotherapy for safe cure, and minimizing treatment-related morbidity. The biological aggressiveness of these cancers is variable and conventional histopathology does not give sufficient information concerning the risk for local or regional recurrence. Laminin-5 is an extracellular matrix protein noted to have special importance for epithelial cell invasion.
PATIENTS AND METHODS
We investigated 43 diagnostic biopsies from patients with T1 tongue cancer treated with wedge excision only. Immunohistochemical analysis was performed using a polyclonal antibody against the gamma2 chain of laminin-5.
RESULTS
Thirty-six specimens were evaluated and 16 patients had a recurrence. A staining pattern of 50% or more was seen in the majority of patients (75%) with tumor recurrence and in fewer patients (45%) without recurrence.
CONCLUSION
In order to optimize treatment for the individual T1 tongue cancer patient, immunostaining against laminin-5 appears to be one possible useful tool.
影响因子：
56.9
作者：
Giannelli, G;FalkMarzillier, J;Quaranta, V
通讯作者：
Quaranta, V