Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
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DOI：
10.3201/eid1412.080941
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发表时间：
2008-12-01
影响因子：
11.8
通讯作者：
Laude, Hubert
中科院分区：
文献类型：
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作者：
Beringue, Vincent;Herzog, Laetitia;Laude, Hubert
为了评估导致罕见牛海绵状脑病 (BSE) 的朊病毒从牛向人类传播的风险，我们给表达人 PrP Met(129) 的小鼠接种了现场分离株。与经典的 ESE 剂不同，L 型朊病毒似乎在这些小鼠体内繁殖，没有明显的传播障碍。 H型朊病毒未能感染小鼠。
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical ESE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.