Hand Joint Space Narrowing and Osteophytes Are Associated with Magnetic Resonance Imaging-defined Knee Cartilage Thickness and Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Hand Joint Space Narrowing and Osteophytes Are Associated with Magnetic Resonance Imaging-defined Knee Cartilage Thickness and Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
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DOI：
10.3899/jrheum.110603
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发表时间：
2012-01-01
影响因子：
3.9
通讯作者：
Eckstein, Felix
中科院分区：
文献类型：
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作者：
Haugen, Ida K.;Cotofana, Sebastian;Eckstein, Felix
Objective.评估手部骨关节炎（OA）的影像学特征是否与定量磁共振成像（MRI）定义的膝关节软骨厚度、影像学膝关节OA和1年结构进展相关。骨关节炎倡议（OAI; 455名女性，平均年龄62.5岁，SD 9.4）共765名参与者获得了手部X线片（基线）、膝关节X线片（基线和第1年）和膝关节MRI（基线和第1年）。手部X线片对骨赘和关节间隙狭窄（JSN）的存在进行评分。膝关节X线片根据Kelling-Lawrence（KL）量表进行评分。通过FLASHwe冠状位图像定量测量股胫内侧和外侧间室的腕骨厚度。我们通过线性和逻辑回归分析了手部OA特征（总骨赘和JSN评分）与膝关节软骨厚度、1年膝关节软骨变薄（高于最小可检测变化）、膝关节OA存在（KL分级>= 3）和膝关节OA进展（KL变化>= 1）之间的横向和纵向相关性。双手OA特征包括在多变量模型中（如果p
Objective. To evaluate whether features of radiographic hand osteoarthritis (OA) are associated with quantitative magnetic resonance imaging (MRI)-defined knee cartilage thickness, radiographic knee OA, and 1-year structural progression.Methods. A total of 765 participants in Osteoarthritis Initiative (OAI; 455 women, mean age 62.5 yrs. SD 9.4) obtained hand radiographs (at baseline), knee radiographs (baseline and Year 1), and knee MRI (baseline and Year 1). Hand radiographs were scored for presence of osteophytes and joint space narrowing (JSN). Knee radiographs were scored according to the Kellgren-Lawrence (KL) scale. Cartilage thickness in the medial and lateral femorotibial compartments was measured quantitatively from coronal FLASHwe images. We examined the cross-sectional and longitudinal associations between features of hand OA (total osteophyte and JSN scores) and knee cartilage thickness, 1-year knee cartilage thinning (above smallest detectable change), presence of knee OA (KL grade >= 3), and progression of knee OA (KL change >= 1) by linear and logistic regression. Both hand OA features were included in a multivariate model (if p