Oestrogen inhibits psoriasis-like dermatitis induced by imiquimod in mice in relation to increased IL-10 producing cells despite elevated expression of IL-22, IL-23, IL-17 mRNA
Oestrogen inhibits psoriasis-like dermatitis induced by imiquimod in mice in relation to increased IL-10 producing cells despite elevated expression of IL-22, IL-23, IL-17 mRNA
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DOI：
10.1111/exd.14688
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发表时间：
2022-10-21
影响因子：
3.6
通讯作者：
Katagiri, Kazumoto
中科院分区：
文献类型：
--
作者：
Kobayashi, Keisuke;Chikazawa, Sakiko;Katagiri, Kazumoto
性激素影响牛皮癣的发展和自然病程。在这里，我们研究了雌性性激素，特别是雌激素，对局部咪喹莫特诱导的牛皮癣样皮炎的影响，这些小鼠接受假手术（sham）或卵巢切除术（OVX），激素替代治疗（HRT）或没有靶向最高生理水平的17 -雌二醇。OVX-、Sham-和hrt治疗小鼠皮肤中中性粒细胞的数量依次较高。然而，在一组实验中，由于hrt治疗小鼠中有少数小鼠出现严重的红斑和鳞屑，三组之间的临床评分没有明显差异。与sham处理小鼠相比，OVX和hrt处理小鼠的白细胞介素(IL)-22和IL-23 mRNA水平升高；hrt处理小鼠IL-10 mRNA水平升高，可能是由于叉头盒P3 (Foxp3)-和IL-10阳性大细胞（可能是巨噬细胞）比例增加所致。此外，hrt处理小鼠的角质层比OVX和sham处理小鼠更致密，loricrin和involucrin的表达也更高。本研究提示雌激素在银屑病发病机制中具有双重潜在作用：通过增加IL-10的产生抑制炎症，通过诱导IL-22和IL-23的表达增强炎症。
Sex hormones influence the development and natural course of psoriasis. Here, we examined the effects of female sex hormones, particularly oestrogen, on psoriasis-like dermatitis induced using topical imiquimod in mice that underwent either sham operation (Sham) or ovariectomy (OVX), with (hormone replacement treatment: HRT) or without 17 beta-oestradiol targeting the maximum physiological levels. The number of neutrophils in the skin was higher in the order of OVX-, Sham-, and HRT-treated mice. However, no significant difference was detected in the clinical scores among the three groups due to severe erythema and scale in a few mice out of HRT-treated mice in a set of experiments. OVX- and HRT-treated mice showed increased mRNA levels of interleukin (IL)-22 and IL-23 compared with Sham-treated mice; increased IL-10 mRNA levels were found in HRT-treated mice, possibly due to an increased proportion of forkhead box P3 (Foxp3)- and IL-10 positive large cells (possibly macrophages). In addition, HRT-treated mice had a more compact stratum corneum with higher expression of loricrin and involucrin than OVX- and Sham-treated mice. This study suggests that oestrogen has a dual potential in the pathogenesis of psoriasis: suppression of inflammation by enhancing IL-10 production and enhancement of inflammation by induction of IL-22 and IL-23 expression.