INHIBITION OF INTESTINAL EPITHELIAL CELL RENEWAL AND MIGRATION INDUCED BY STARVATION
INHIBITION OF INTESTINAL EPITHELIAL CELL RENEWAL AND MIGRATION INDUCED BY STARVATION
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DOI：
10.1152/ajplegacy.1963.205.5.868
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发表时间：
1963-01-01
影响因子：
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通讯作者：
LIPKIN, M
中科院分区：
文献类型：
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作者：
BROWN, HO;LEVINE, ML;LIPKIN, M
在小鼠饥饿后，测量肠上皮细胞的更新速率。采用胸苷-H_3注射和微量放射自显影，胸苷-C_1_4注射和化学提取法。在极度饥饿后，细胞更新率降低到正常速度的一半左右。上皮细胞的形态学改变和分化障碍伴随着这种变化。上皮细胞向绒毛尖端的迁移率也降低。
Following starvation in mice, the rate of cell renewal of intestinal epithelium was measured. Injection of thymidine-H3 and microautoradiography, and thymidine-C14 and chemical extraction procedure were utilized. Cell renewal was reduced to about one-half the normal rate following extreme starvation. Morphological changes and impaired differentiation of the epithelial cells accompanied this change. The rate of migration of the epithelial cells to the villus tips was also reduced.