Does mixed connective tissue disease exist? Yes
Does mixed connective tissue disease exist? Yes
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DOI：
10.1016/j.rdc.2005.04.007
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发表时间：
2005-08-01
影响因子：
2.3
通讯作者：
Smolen, JS
中科院分区：
文献类型：
--
作者：
Aringer, M;Steiner, G;Smolen, JS
对于具有类风湿性关节炎、系统性硬化症的有限皮肤形式和炎性肌病的组合特征的患者，混合性结缔组织病（MCTD）的概念通常有助于预测和诊断器官问题并相应地教育患者。对于抗U1核糖核蛋白（U1-RNP）的高滴度IgG抗体，这一概念得到了特异性血清学标志物的支持，抗U1-RNP和抗异质性核核糖核蛋白（hnRNP）-A2的自身抗体显示出与识别表位相关的MCTD特异性。此外，MCTD与HLA-DR 4的关联将其与系统性红斑狼疮和系统性硬化症区分开来，并说明其是一种疾病实体，而不是尚未分化的胶原血管疾病的混合物。作者认为，这一概念在日常实践中是有用的，并且在MCTD构成其自身的疾病实体的想法中是准确的。
For patients who have combined features of rheumatoid arthritis, the limited cutaneous form of systemic sclerosis, and inflammatory myopathies, the concept of mixed connective tissue disease (MCTD) often helps to predict and diagnose organ problems and to educate the patient accordingly. With high titer IgG antibodies to U1 ribonucleoprotein (U1-RNP), this concept is supported by a specific serologic marker, and autoantibodies to U1-RNP and to heterogeneous nuclear ribonucleoprotein (hnRNP)-A2 display MCTD specificity with regard to the recognized epitopes. in addition, the association of MCTD with HLA-DR4 distinguishes it from systemic erythematosus lupus and systemic sclerosis, and speaks to its being a disease entity, rather than a mixture of yet undifferentiated collagen vascular diseases. The authors believe that the concept is useful in daily practice and accurate in the idea that MCTD constitutes a disease entity of its own.