Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma
Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma
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DOI：
10.1111/j.1365-2141.2004.05353.x
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发表时间：
2005-02-01
影响因子：
6.5
通讯作者：
Jarrett, RF
中科院分区：
文献类型：
--
作者：
Cordano, P;Lake, A;Jarrett, RF
人类白介素 6 基因的 -174 位存在单核苷酸多态性 (SNP)。年轻人患霍奇金淋巴瘤 (HL) 的风险随着该位置 C 等位基因数量的增加而降低。我们分析了该 SNP 对 HL 发病率和结果的影响。根据年龄、组织学亚型和 Epstein-Barr 病毒状态分层，对 408 例病例和 349 例对照的 DNA 样本进行了筛选和分析。尽管年轻人患经典 HL 的风险随着 C 等位基因的增加而降低，但病例对照差异并不显着。在年轻人 (n = 21) 的结节性淋巴细胞为主的 HL 中观察到 G 等位基因过多，这一点很重要。
A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.