Studies on the drug release properties of polysaccharide multilayers encapsulated ibuprofen microparticles
Studies on the drug release properties of polysaccharide multilayers encapsulated ibuprofen microparticles
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DOI：
10.1021/la010201w
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发表时间：
2001-08-21
期刊：
影响因子：
3.9
通讯作者：
Möhwald, H
中科院分区：
文献类型：
--
作者：
Qiu, XP;Leporatti, S;Möhwald, H
为了控制释放的目的，尺寸在5 μ m和40 μ m之间的ICPs微晶体已经用ICPs多层膜（PEM）封装。的封装是通过一种新的涂层技术的基础上逐层组装带相反电荷的聚电解质。生物相容性的聚电解质，包括壳聚糖，硫酸葡聚糖，羧甲基纤维素，和海藻酸钠被用作涂层材料，以制造不同的壳厚度从20到60 nm的PEM胶囊。采用UV光谱法监测pH 1.4和pH 7.4溶液中的药物释放过程。结果发现，布洛芬从这些微胶囊中的释放取决于几个参数，如晶体大小，PEM胶囊厚度，和在本体溶液中的核心材料的溶解度。我们的研究结果表明，多糖胶囊可以大大延长胶囊化药物晶体的释放时间。
Ibuprofen microcrystals sized between 5 and 40 mum have been encapsulated with polyelectrolyte multilayers (PEM) for the purpose of controlled release. The encapsulation was accomplished by a novel coating technology based on layer-by-layer assembly of oppositely charged polyelectrolytes. The biocompatible polyelectrolytes including chitosan, dextran sulfate, carboxymethyl cellulose, and sodium alginate were used as coating materials to fabricate PEM capsules with varying shell thicknesses from 20 to 60 nm. UV spectroscopy was employed to monitor the drug release processes in both pH 1.4 and pH 7.4 solutions. It was found that the release of ibuprofen from these microcapsules is dependent on several parameters such as the crystal size, the PEM capsule thickness, and the solubility of the core material in the bulk solutions. Our results reveal that the polysaccharide capsules can substantially prolong the release time of the encapsulated drug crystals.