In vitro activity of quinolines against Plasmodium falciparum in Gabon
In vitro activity of quinolines against Plasmodium falciparum in Gabon
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DOI：
10.1016/j.actatropica.2003.11.001
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发表时间：
2004-03-01
期刊：
影响因子：
2.7
通讯作者：
Kremsner, PG
中科院分区：
文献类型：
--
作者：
Ramharter, M;Wernsdorfer, WH;Kremsner, PG
恶性疟原虫对抗疟药物的敏感性评价对于疟疾流行地区具有重要意义。2002年，我们进行了一项随访研究，通过测量鞭毛体成熟抑制来监测最常用的喹啉类药物对加蓬兰巴内新鲜恶性疟原虫分离株的体外活性。氯喹、奎宁和甲氟喹的平均50%有效浓度水平分别为5.5 μ mol/l血液、286 nmol/l血液培养基混合物（BMM）和1.1 μ mol/l血液。所有分离株（n = 40）被发现是高度耐氯喹。一株分离株对甲氟奎耐药，五株分离株呈临界耐药。所有菌株的抑制奎宁浓度低于耐药阈值（n = 43）。除了观察到越来越多的边界耐药菌株甲氟喹，一个非常高的寄生虫抗药性氯喹-仍然正式的第一线抗疟药在加蓬-似乎是特别关注。(C)2003 Elsevier B. V.保留所有权利。
The assessment of drug sensitivity of Plasmodium falciparum to antimalarial drugs is of vital interest for malaria endemic regions. We conducted a follow-up study to monitor the in vitro activity of the most commonly used quinolines against fresh P falciparum isolates in Lambarene, Gabon by measuring schizont maturation inhibition in 2002. Mean 50% effective concentration levels for chloroquine, quinine, and mefloquine were 5.5 mumol/l blood, 286 nmol/l blood medium mixture (BMM), and 1.1 mumol/l blood, respectively. All isolates (n = 40) were found to be highly resistant to chloroquine. One isolate was resistant to mefloquine and five isolates were presenting borderline-resistance. All isolates were inhibited by quinine concentrations below the threshold of resistance (n = 43).Besides the observation of an increasing number of borderline resistant isolates to mefloquine, an extremly high parasite resistance to chloroquine-still officially the first line antimalarial in Gabon-seems to be of particular concern. (C) 2003 Elsevier B.V. All rights reserved.