Hair Cortisol as a Biomarker of Traumatization in Healthy Individuals and Posttraumatic Stress Disorder Patients
Hair Cortisol as a Biomarker of Traumatization in Healthy Individuals and Posttraumatic Stress Disorder Patients
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DOI：
10.1016/j.biopsych.2013.03.011
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发表时间：
2013-11-01
影响因子：
10.6
通讯作者：
Stalder, Tobias
中科院分区：
文献类型：
--
作者：
Steudte, Susann;Kirschbaum, Clemens;Stalder, Tobias
背景：先前关于创伤后应激障碍（PTSD）的内分泌相关性的证据是相当不一致的。头发中皮质醇的分析是最近的方法学发展，可能会提高此类研究中长期皮质醇评估的质量。在这里，我们使用这种方法来密切评估头发皮质醇与创伤相关的特征和PTSD症状patterns.Methods的关系：头发皮质醇浓度（HCC），昼夜唾液皮质醇，和相关的心理测量数据进行了评估，在匹配组的28例PTSD患者和27创伤和32非创伤健康对照组。皮质醇水平进行了定量液相色谱串联mass spectrometry.Results：创伤后应激障碍患者和创伤对照组表现出59%和51%，分别低于非创伤对照组的肝癌。头发皮质醇浓度被认为是负相关的入侵症状的严重程度，不同的一生创伤事件的数量，创伤的频率，创伤后的时间间隔。HCC协会的整体模式没有反映在短期唾液皮质醇findings.Conclusions：我们的研究结果表明，创伤暴露本身，无论是在没有或存在PTSD，是一个重要的长期基础皮质醇水平相关。特别是，创伤后较长时间内发生多起事件和侵入症状严重程度增加可能与皮质醇减少症有关。事实上，HCC的研究结果并不一致，唾液皮质醇的数据强调了皮质醇评估方法的重要性，并强调了头发皮质醇分析的实用性，为未来的生物精神病学研究。
Background: Previous evidence on endocrine correlates of posttraumatic stress disorder (PTSD) has been rather inconsistent. The analysis of cortisol in hair is a recent methodological development that may increase the quality of long-term cortisol assessments in such research. Here, we use this method to closely assess hair cortisol relationships with trauma-related characteristics and PTSD symptom patterns.Methods: Hair cortisol concentrations (HCC), diurnal salivary cortisol, and relevant psychometric data were assessed in matched groups of 28 PTSD patients and 27 traumatized and 32 nontraumatized healthy control subjects. Cortisol levels were quantified by liquid chromatography tandem mass spectrometry.Results: Posttraumatic stress disorder patients and traumatized control subjects exhibited 59% and 51% lower HCC than nontraumatized control subjects, respectively. Hair cortisol concentrations were found to be negatively related to the severity of intrusion symptoms, the number of different lifetime traumatic events, the frequency of traumatization, and the time interval since traumatization. The overall pattern of HCC associations was not reflected in short-term salivary cortisol findings.Conclusions: Our results indicate that trauma exposure per se, either in the absence or presence of PTSD, is a crucial correlate of long-term basal cortisol levels. Particularly, the experience of multiple events with a longer time since traumatization and an increased severity of intrusion symptoms may be related to hypocortisolism. The fact that HCC findings were not consistently seen in salivary cortisol data underscores the importance of the method of cortisol assessment and highlights the utility of hair cortisol analyses for future biological psychiatry research.