Sequence and structure space of RNA-binding peptides
Sequence and structure space of RNA-binding peptides
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DOI：
10.1002/bip.10429
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发表时间：
2003-09-01
期刊：
影响因子：
2.9
通讯作者：
Frankel, AD
中科院分区：
文献类型：
--
作者：
Das, C;Frankel, AD
RNA结合肽的研究，特别是最近的组合文库实验，已经证明了不同的肽序列和结构可以用于识别特定的RNA位点。大量能够与特定位点结合的序列的鉴定提供了广泛的系统发育信息，用于推断识别的基本原理。RNA结合肽在大型序列库中的高频率表明了进化序列特异性结合剂的合理途径，促进了新结合分子的设计，并可能反映了自然进化的特征。(C)2003 Wiley Periodicals，Inc.
Studies of RNA-binding peptides, and recent combinatorial library experiments in particular, have demonstrated that diverse peptide sequences and structures can be used to recognize specific RNA sites. The identification of large numbers of sequences capable of binding to a particular site has provided extensive phylogenetic information used to deduce basic principles of recognition. The high frequency at which RNA-binding peptides are found in large sequence libraries suggests plausible routes to evolve sequence-specific binders, facilitating the design of new binding molecules and perhaps reflecting characteristics of natural evolution. (C) 2003 Wiley Periodicals, Inc.