Integrating Sugar and Dopamine into One Polymer: Controlled Synthesis and Robust Surface Modification
Integrating Sugar and Dopamine into One Polymer: Controlled Synthesis and Robust Surface Modification
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将糖和多巴胺整合成一种聚合物：受控合成和稳健的表面改性
DOI：
10.1002/marc.201600548
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发表时间：
2017
影响因子：
4.6
通讯作者：
Chen Gaojian
中科院分区：
文献类型：
--
作者：
Peng Lun;Li Zhiyun;Li Xiaohui;Xue Hui;Zhang Weidong;Chen Gaojian
附着在表面上的糖共聚物具有以高度特异性的方式结合某些碳水化合物结合蛋白的能力，正因为如此，糖共聚物修饰表面的制造已经发展成为生物响应系统的有效途径。首次成功地通过室温单电子转移引发和通过自由基加成断裂链转移技术的传播以良好控制的方式制备了含有糖和邻苯二酚官能团的聚（N-3，4-二羟基苯乙基甲基丙烯酰胺-co-2-（甲基丙烯酰胺基）吡喃葡萄糖）共聚物。聚合行为进行了研究，它提出了控制功能与一级动力学和分子量和单体转化率之间的线性关系。此外，这些共聚物还用于修饰不同类型的表面（硅、钢和塑料），通过水接触角、傅里叶变换红外光谱（FT-IR）、X射线光电子能谱、扫描电子显微镜和能量色散X射线（SEM/EDX）、原子力显微镜和共聚焦显微镜测量，研究表面性质和特异性凝集素结合能力。
Glycopolymers attached to a surface possess the ability to bind to certain carbohydrate binding proteins in a highly specific manner, and because of this, the fabrication of glycopolymer‐modified surfaces has evolved as an effective route toward bioresponsive systems. Poly(N‐3,4‐dihydroxybenzenethyl methacrylamide‐co‐2‐(methacrylamido) glucopyranose) copolymers, containing sugar and catechol functionalities, are for the first time successfully prepared in a well‐controlled manner via room temperature single‐electron transfer initiation and propagation through radical addition fragmentation chain transfer technique. The polymerization behavior is investigated and it presents controlled features with first‐order kinetics and linear relationships between molecular weights and monomer conversions. Moreover, the copolymers are used to modify different types of surfaces (silicon, steel, and plastic), the properties of the surfaces and the specific lectin‐binding abilities are investigated by a combination of water contact angle, Fourier transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectra, scanning electron microscopy with energy dispersive X‐ray (SEM/EDX), atomic force microscopy, and confocal microscope measurements.