Long term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain
Long term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain
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DOI：
10.1016/j.devbrainres.2005.03.007
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发表时间：
2005-06-09
期刊：
影响因子：
--
通讯作者：
El Sabban, M
中科院分区：
文献类型：
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作者：
Mikati, MA;Zeinieh, MP;El Sabban, M
10日龄的幼鼠（P10）急性缺氧（低至4%O-2）成年后攻击性（处理试验）、记忆障碍（水迷宫试验）和CA 1细胞计数减少。慢性缺氧（从P0到P21，10%O-2）的幼鼠具有增加的攻击性、多动性（旷场试验）和减少的CA 1细胞计数。慢性缺氧叠加急性缺氧的后果是没有什么不同的慢性缺氧。(c)2005 Elsevier B. V.保留所有权利。
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O-2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O-2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia. (c) 2005 Elsevier B.V. All rights reserved.