Effects of Cognitive Training on Gray Matter Volumes in Memory Clinic Patients with Subjective Memory Impairment
Effects of Cognitive Training on Gray Matter Volumes in Memory Clinic Patients with Subjective Memory Impairment
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DOI：
10.3233/jad-131889
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
--
作者：
Engvig, Andreas;Fjell, Anders M.;Walhovd, Kristine B.
主观记忆障碍（SMI）是阿尔茨海默病的常见风险因素，几乎没有既定的治疗选择。在这里，我们调查了两个月的情景记忆训练对19名记忆诊所的SMI患者的局部脑萎缩的影响。我们使用了一种敏感的纵向磁共振成像方案，并将患者与42名匹配的健康志愿者进行了比较，这些志愿者被随机分配到一个进行相同训练的组，或一个没有训练的对照组。干预后，SMI样本表现出结构性灰质体积增加的大脑区域，包括情节记忆网络，与健康的训练参与者相当程度的皮质体积扩张。此外，我们发现健康训练组的海马体积显著增加，但SMI组没有。尽管如此，患者组左海马体积变化的个体差异与训练后言语回忆的改善有关。目前的结果加强了早期的研究，表明在衰老过程中大脑的可塑性是完整的，并进一步表明，与训练相关的大脑变化在认知障碍的早期形式中也是明显的。
Subjective memory impairment (SMI) is a common risk factor for Alzheimer's disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy in 19 memory clinic patients with SMI. We used a sensitive longitudinal magnetic resonance imaging protocol and compared the patients with 42 matched healthy volunteers randomly assigned to a group performing the same training, or a no- training control group. Following intervention, the SMI sample exhibited structural gray matter volume increases in brain regions encompassing the episodic memory network, with cortical volume expansion of comparable extent as healthy training participants. Further, we found significant hippocampal volume increases in the healthy training group but not in the SMI group. Still, individual differences in left hippocampal volume change in the patient group were related to verbal recall improvement following training. The present results reinforce earlier studies indicating intact brain plasticity in aging, and further suggest that training- related brain changes can be evident also in the earliest form of cognitive impairment.