A primate model for studying focal dystonia and repetitive strain injury: Effects on the primary somatosensory cortex
A primate model for studying focal dystonia and repetitive strain injury: Effects on the primary somatosensory cortex
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DOI：
10.1093/ptj/77.3.269
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发表时间：
1997-03-01
期刊：
影响因子：
3.2
通讯作者：
Jenkins, WM
中科院分区：
文献类型：
--
作者：
Byl, NN;Merzenich, MM;Jenkins, WM
背景和目的。与工作相关的重复性劳损（RSIs）正在增加，目前的治疗策略往往无法使受伤的人重返工作岗位。这项研究记录了使用两种不同的运动策略，积极的，重复的手关闭和打开的神经后果。方法.两只猫头鹰猴被训练20周，以对抗80 g的力重复关闭手柄（每天3-400次试验，训练准确率为80%-90%）。一只猴子使用高度关节化的手挤压策略，另一只猴子使用近端手臂拉动策略。运动性能的变化进行了分析，并进行了比较，与未经训练的对照动物和未经训练的猴子的一侧的训练的初级感觉皮层（3b区）的手代表的电生理图。结果使用关节手挤压策略的猴子表现出运动退化和去分化的手表示在3b区的正常急剧分离的地区。轻度退化的手表示在猴子使用近端手臂拉策略，但没有运动功能障碍。结论和讨论。专注的、高度清晰的、重复的手指挤压会降低手的表征能力，并干扰运动控制。一个近端的，更可变的重复策略最大限度地减少了感觉退化和保留运动控制。恢复手的代表性可能是治疗慢性RSI和局灶性手肌张力障碍患者的关键部分。
Background and Purpose. Job-related repetitive strain injuries (RSIs) are increasing, and current treatment strategies often fail to return injured people to work. This study documented the neural consequences of using two different movement strategies for active, repetitive hand closing and opening. Methods. Two owl monkeys were trained for 20 weeks to repetitively close a handpiece against an 80-g force (3-400 trials per day, training at 80%-90% accuracy). One monkey used a highly articulated hand-squeezing strategy, and the other monkey used a proximal arm-pulling strategy. Changes in motor performance were analyzed, and the electrophysiological maps of the hand representation on the trained primary sensory cortex (area 3b) were compared with those of untrained control animals and the untrained sides of the trained monkeys. Results. The monkey using the articulated hand-squeezing strategy showed motor deterioration and dedifferentiation of the normally sharply segregated areas of the hand representation in area 3b. Mild degradation of the hand representation was measured in the monkey using the proximal arm-pulling strategy, but there was no motor dysfunction. Conclusion and Discussion. Attended, highly articulated, repetitive finger squeezing degrades the hand representation and interferes with motor control. A proximal, more variable repetitive strategy minimized the sensory degradation and preserved motor control. Restoring the hand representation may be a critical part of treatment for patients with chronic RSI and focal hand dystonia.