Neural activity related to drug craving in cocaine addiction
Neural activity related to drug craving in cocaine addiction
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DOI：
10.1001/archpsyc.58.4.334
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发表时间：
2001-04-01
影响因子：
--
通讯作者：
Drexler, KPG
中科院分区：
文献类型：
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作者：
Kilts, CD;Schweitzer, JB;Drexler, KPG
背景：强效可卡因依赖和成瘾通常与频繁和强烈的药物需求或渴望相关，这些需求或渴望是由与过去吸毒相关的内部或环境线索触发的。方法：使用 Water O 15 正电子发射断层扫描 (PET) 研究来定位 8 名强效可卡因依赖的非洲裔美国男性中与线索诱发的药物渴望相关的突触活动的变化。在一种新颖的方法中，自传体记忆的脚本引导意象被用作个性化线索，在 PET 图像采集过程中内部生成可卡因渴望状态和 2 个控制（即愤怒和中性情景记忆回忆）状态。 结果：个性化药物使用和愤怒相关脚本的心理意象与强烈的药物渴望或愤怒的自我评级以及心率的类似变化相关。与中性意象控制条件相比，意象诱发的药物渴望与双侧（右半球杏仁核激活大于左半球）杏仁核、左侧岛叶和前扣带回、右侧胼胝体下回和伏核区的激活有关。与愤怒控制条件相比，内部产生的药物渴望与双侧岛叶和胼胝体下皮层、左侧海马体、前扣带皮层和脑干的激活有关。全脑逐像素搜索表明，意象诱发的可卡因渴望与分布部位的局部脑血流量 (rCBF) 之间存在显着的正相关和负相关。 结论：收集到的研究结果表明，与渴望相关的边缘系统、旁边缘系统和纹状体大脑区域网络的激活，包括涉及刺激-奖励关联的结构 （杏仁核）、激励动机（胼胝体下回/伏隔核）和预期（前扣带皮层）。
Background: Crack cocaine dependence and addiction is typically associated with frequent and intense drug wanting or craving triggered by internal or environmental cues associated with past drug use.Methods: Water O 15 positron emission tomography (PET) studies were used to localize alterations in synaptic activity related to cue-induced drug craving in 8 crack cocaine-dependent African American men. In a novel approach, script-guided imagery of autobiographical memories were used as individualized cues to internally generate a cocaine craving state and 2 control (ie, anger and neutral episodic memory recall) states during PET image acquisition.Results: The mental imagery of personalized drug use and anger-related scripts was associated with self-ratings of robust drug craving or anger, and comparable alterations in heart rate. Compared with the neutral imagery control condition, imagery-induced drug craving was associated with bilateral (right hemisphere amygdala activation greater than left) activation of the amygdala, the left insula and anterior cingulate gyrus, and the right subcallosal gyrus and nucleus accumbens area. Compared with the anger control condition, internally generated drug craving was associated with bilateral activation of the insula and subcallosal cortex, left hippocampus, and anterior cingulate cortex and brainstem. A brain-wide pixel-by-pixel search indicated significant positive and negative correlations between imagery-induced cocaine craving and regional cerebral blood flow (rCBF) in distributed sites.Conclusions: The collected findings suggest the craving-related activation of a network of limbic, paralimbic, and striatal brain regions, including structures involved in stimulus-reward association (amygdala), incentive motivation (subcallosal gyrus/nucleus accumbens), and anticipation (anterior cingulate cortex).