Treatment of Resistant Fever: New Method of Local Cerebral Cooling
Treatment of Resistant Fever: New Method of Local Cerebral Cooling
复制标题
DOI：
10.1007/s12028-010-9451-1
复制
发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Keller, Emanuela
中科院分区：
文献类型：
--
作者：
Mink, Susanne;Schwarz, Urs;Keller, Emanuela
发热在神经重症监护患者中很常见，对神经系统结局有负面影响。这项前瞻性观察性研究的目的是（1）评价在神经重症监护病房（NICU）患者的日常环境中使用新开发的颈垫进行冷却的可行性，以及（2）评价其作为替代终点的有效性，以表明颈部冷却作为顽固性发热的新方法的可行性。具有两种不同形状的特别适用的冷却颈垫中的一种。应用降温颈垫后8h内，对脑、血、膀胱温度进行密切监测，脑、血、膀胱温度从0h开始显著降低，至5h降至最低（P < 0.01）。5小时后，所有患者的三个部位的温度都恢复正常，而不是持续冷却。本研究表明，在NICU患者的日常环境中，使用新开发的颈垫对顽固性发热进行局部冷却是可行的。
Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever.Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour 8.The brain, blood, and urinary bladder temperatures decreased significantly from hour 0 to a minimum in hour 5 (P < 0.01). After hour 5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted.This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patients.