MEDIAN RHOMBOID GLOSSITIS - CANDIDIASIS AND NOT A DEVELOPMENTAL ANOMALY
MEDIAN RHOMBOID GLOSSITIS - CANDIDIASIS AND NOT A DEVELOPMENTAL ANOMALY
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DOI：
10.1111/j.1365-2133.1975.tb06513.x
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发表时间：
1975-01-01
影响因子：
10.3
通讯作者：
COOKE, BED
中科院分区：
文献类型：
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作者：
COOKE, BED
10例临床表现为正中菱形舌炎的舌中线病变患者的活检中，角化不全上皮浅层均发现念珠菌菌丝。有不同程度的急性念珠菌感染，上皮细胞和慢性炎症细胞的斑块被C。白色念珠菌叠加在角化不全上皮上。试管状的深上皮嵴，其中一些分支，也是非常引人注目的特征。选择的位置表明，盲肠孔，也许是凹陷的中线中缝的舌头有利于定位C。感染从这些地点，它横向传播，并以其慢性化为特点。抗真菌治疗在这些患者中显示出非常有限的成功。据称，对于表面光滑、结节状或裂隙状、无乳突的无症状病例，没有必要或有效的治疗，但对于表面裂隙状、伴有持续性疼痛性舌炎的病变，则需要切除。
Candida hyphae were found within the superficial layers of the parakeratotic epithelium in all biopsies from 10 patients presenting with midline lesions of the tongue which clinically presented as median rhomboid glossitis. There were varying degrees of a superimposed acute candidiasis, with a plaque of epithelial cells and chronic inflammatory cells invaded by C. albicans superimposed upon the parakeratotic epithelium. Test-tube like deep epithelial ridges, some of which branched, were also very striking features. The site of election suggested that the foramen caecum and perhaps the depression of the midline raphe of the tongue favour the localization of C. infection. From these sites it spreads laterally and is characterized by its chronicity. Antifungal therapy had shown very limited success in these patients. It is stated that no treatment is either necessary or effective in asymptomatic cases with a smooth, nodular or fissured surface devoid of papillae, but that in lesions with a fissured surface associated with persistent painful glossitis excision is indicated.