Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming
Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming
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DOI：
10.1007/s12311-011-0269-y
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发表时间：
2011-09-01
期刊：
影响因子：
3.5
通讯作者：
Argyropoulos, Giorgos P.
中科院分区：
文献类型：
--
作者：
Argyropoulos, Giorgos P.
最近对小脑认知和语言功能的研究使小脑参与处理时间上连续的语言输入的观点变得可信。为了验证这一假设，我们构建了一个简单的词汇决策任务来研究经颅磁刺激对两个不同小脑部位的影响是否会对联想启动而不是语义启动产生选择性影响。这是第一个应用经颅磁刺激小脑来完成语言任务的实验。结果显示，在第一阶段的参与中，刺激小脑内侧部位后，词汇决策准确性选择性下降。最重要的是，他们还证明了在刺激同一部位后，联想启动大小的选择性增加，这不能归因于感觉运动表现或准确率的变化。这一发现是在领域一般联想小脑计算的背景下讨论的。
Recent research in cerebellar cognitive and linguistic functions makes plausible the idea that the cerebellum is involved in processing temporally contiguous linguistic input. In order to assess this hypothesis, a simple lexical decision task was constructed to study whether the effect of transcranial magnetic stimulation on two different cerebellar sites would have a selective impact on associative as opposed to semantic priming. This is the first experiment applying transcranial magnetic stimulation of the cerebellum to a linguistic task. The results show a selective drop in lexical decision accuracy after stimulation of a medial cerebellar site in the first session of participation. Most importantly, they also demonstrate a selective increase of associative priming sizes after stimulation of the same site that cannot be attributed to changes in sensorimotor performance or in accuracy rates. The finding is discussed within the context of domain-general associative cerebellar computations.