Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra
Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra
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DOI：
10.1021/np040112u
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发表时间：
2004-12-01
影响因子：
5.1
通讯作者：
Sheu, JH
中科院分区：
文献类型：
--
作者：
Ahmed, AF;Su, JH;Sheu, JH
从台湾软珊瑚Sinularia scabra的有机提取物中分离得到三个新的去甲二萜类化合物：scabrolides E-G（1-3）和dissectolide A（4）。1-3的结构是在广泛的光谱分析的基础上，并通过比较其光谱数据与已知的相关代谢产物的结构来确定的。发现代谢产物1对Hepa 59 T/VGH和KB细胞系的生长表现出显著的细胞毒性。
Three new norditerpenoids, scabrolides E-G (1-3), and dissectolide A (4) have been isolated from the organic extract of a Taiwanese soft coral Sinularia scabra. The structures of 1-3 were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of the known related metabolites. Metabolite 1 was found to exhibit significant cytotoxicity against the growth of Hepa59T/VGH and KB cell lines.