Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.
Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.
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DOI：
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发表时间：
1995-02
期刊：
影响因子：
11.2
通讯作者：
M. Blaser;P. Chyou;A. Nomura
中科院分区：
文献类型：
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作者：
M. Blaser;P. Chyou;A. Nomura
幽门螺杆菌是胃癌、胃溃疡和十二指肠溃疡的重要危险因素，但大多数感染者不会发展为疾病。我们检验了获得年龄的两个相关性，兄弟姐妹大小和出生顺序，以评估早期获得幽门螺杆菌是这些疾病发展的风险因素的假设。在夏威夷对一群日裔美国男性进行的早期嵌套病例对照研究中，幽门螺杆菌感染的证据与随后的1968-1989年间胃癌或胃或十二指肠溃疡的发生有关。目前的分析包括102名、147名和男性，他们分别患有远端胃腺癌、胃溃疡和十二指肠溃疡，并分别设立了匹配的对照组。兄弟姐妹的大小和出生顺序数据被分析为这些疾病发生的危险因素。感染幽门螺杆菌但没有感染幽门螺杆菌的男性来自较大的兄弟姐妹(优势比2.06)和较高的出生顺序(优势比1.67)，患胃癌的风险更高。幽门螺杆菌感染的男性而不是出生顺序较高的未感染男性患胃溃疡的风险增加(优势比1.64)，但不是十二指肠溃疡。这些数据与早期获得幽门螺杆菌会增加患胃癌和胃溃疡的风险，但不会增加十二指肠溃疡的假设是一致的。
Helicobacter pylori is an important risk factor for gastric cancer, gastric ulcer, and duodenal ulcer, yet most infected persons do not develop disease. We examined two correlates of acquisition age, sibship size and birth order, to evaluate the hypothesis that early life acquisition of H. pylori is a risk factor for the development of these illnesses. In earlier nested case-control studies of a cohort of Japanese American men in Hawaii, evidence of H. pylori infection was associated with the development of gastric cancer or gastric or duodenal ulceration during the subsequent period, 1968-1989. The present analysis included 102, 147, and 64 men who developed adenocarcinoma of the distal stomach, gastric ulcer, and duodenal ulcer, respectively, and a matched control for each. Sibship size and birth order data were analyzed as risk factors for development of these diseases. H. pylori-infected but not H. pylori-uninfected men from larger sibships (odds ratio, 2.06) and of higher birth order (odds ratio, 1.67) were at increased risk for developing gastric cancer. H. pylori- infected men but not uninfected men at higher birth order had increased risk of gastric (odds ratio, 1.64) but not duodenal ulcers. These data are consistent with the hypothesis that early life acquisition of H. pylori increases the risk of developing both gastric cancer and gastric ulcer but not duodenal ulcer.