High HIV risk profile among female commercial sex workers in Vinnitsa, Ukraine.
High HIV risk profile among female commercial sex workers in Vinnitsa, Ukraine.
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乌克兰文尼察女性商业性工作者的艾滋病毒风险较高。
DOI：
10.1136/sti.2004.011890
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发表时间：
2005
影响因子：
3.6
通讯作者：
Polonets,V
中科院分区：
文献类型：
--
作者：
Kyrychenko,P;Polonets,V
虽然来自其他国家的许多研究记录了性病临床患者的乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染率，但来自印度的数据很少。在本报告中，我们通过血清学和分子诊断方法分析了性病患者的HBV和HCV感染率。研究对象是1998年9月至2000年8月期间在金奈政府总医院性病门诊就诊的有症状性传播疾病患者（n= 143），在获得知情同意后随机纳入性病研究。用ELISA试剂盒检测血样中肝炎和HIV标志物；HBsAg、HBeAg/anti-HBe（美国Biorad实验室）、抗hcv（英国Murex Diagnostics）、抗hiv 1和抗hiv 2（印度Xyton Diagnostics）。另一套EIA试剂盒（法国赛诺菲巴斯德公司）证实hiv阳性。采用聚合酶链反应（PCR） 3和RT-PCR4方法检测HBV DNA和HCV RNA。HBV和HCV的血清学和分子标记谱如表1所示。37例（25.9%）患者HBsAg阳性，25例（67.6%）患者检出HBV DNA。28例HBeAg阳性病例中有23例检测到HBV DNA， 9例抗hbe阳性病例中有2例检测到HBV DNA。女性HBV总阳性率明显高于男性（33.7% vs 15.9%; p, 0.05）。6例（4.2%）患者抗- hcv阳性，其中5例HCV-RNA阳性。RTPCR在2例抗hcv阴性患者中检测到HCV-RNA。HCV总体患病率为5.6%。抗hiv阳性24例（16.8%）。男性HIV阳性率明显高于女性(27%(17/63)vs 8.8%(7/80)；p 0.05)。在5例（13.5%）HBV感染患者和2例（25%）HCV RNA单独阳性的HCV阳性患者中观察到HIV合并感染。注射吸毒（7.7%）、输血史（5.6%）和同性性接触（2.9%）的流行率较低，这些危险因素与艾滋病的流行率无相关性
While many studies from other countries1 2 document hepatitis B virus (HBV) and hepatitis C virus (HCV) infection rates in STD clinic patients, very few data are available from India. In the present report, we have analysed the rate of HBV and HCV infections in STD patients by using serological and molecular methods of diagnosis. The study subjects were symptomatic STD patients (n= 143), who attended the STD clinic, Government General Hospital, Chennai, between September 1998 and August 2000, randomly included for a study on STDs after obtaining informed consent. Blood samples were evaluated for hepatitis and HIV markers by ELISA kits; HBsAg, HBeAg/anti-HBe (Biorad laboratories, USA), anti-HCV (Murex Diagnostics, UK), anti-HIV 1 and 2 (Xyton Diagnostics, India). Anti-HIV positivity was confirmed by another EIA kit (Sanofi Pasteur, France). Detection of HBV DNA and HCV RNA was performed by polymerase chain reaction (PCR) 3 and RT-PCR4 methods.The serological and molecular marker profile for HBV and HCV is shown in table 1. HBsAg was positive in 37 (25.9%) patients, while HBV DNA was detected in 25 (67.6%) of them. HBV DNA was detected in 23 of 28 HBeAg positives and two of nine anti-HBe positive cases. The overall HBV positivity rate was significantly higher in females than in males (33.7% v 15.9%; p, 0.05). Anti-HCV was positive in six (4.2%) patients and five of them showed HCV-RNA positivity. RTPCR additionally detected HCV-RNA in two anti-HCV negative patients. The overall HCV prevalence was 5.6%. Anti-HIV positivity was seen in 24 (16.8%) patients. Men had a significantly higher HIV positivity rate compared to women (27%(17/63) v 8.8%(7/80); p, 0.05). HIV co-infection was observed in five (13.5%) of the HBV infected patients and in two (25%) of the HCV positive patients in whom HCV RNA alone was positive. There was a low prevalence of injection drug use (7.7%), history of blood transfusion (5.6%), and homosexual contact (2.9%) and these risk factors showed no correlation with