Differential absolute plasma IL-6 concentrations between two immunoassay platforms in intensive care unit patients with COVID-19.
Differential absolute plasma IL-6 concentrations between two immunoassay platforms in intensive care unit patients with COVID-19.
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DOI：
10.2217/bmm-2023-0073
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发表时间：
2023-05
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
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作者：
探讨血浆IL-6水平在不同生物标志物平台上是否相似，以及与COVID-19临床结果的关联。采用罗氏Elecsys IL-6检测和Meso Scale Discovery检测191例COVID-19患者的血浆IL-6浓度。不同平台间IL-6水平相关性高（r = 0.87; 95% CI: 0.82 ~ 0.89）；然而，一致性较低（偏倚：147.2 pg/ml； 95%一致性限：-489.5-783.9 pg/ml）。与Meso Scale Discovery相比，Roche预测有创机械通气和住院死亡率的最佳IL-6阈值分别高出3倍和3.4倍。使用罗氏平台预测预后的绝对IL-6阈值始终较高，而根据生物标志物平台，预测预后的IL-6阈值有所不同。COVID-19患者的IL-6水平在两种不同的生物标志物平台之间存在相关性，但在使用罗氏仪器测量的样本中，绝对IL-6水平始终高于Meso Scale Discovery设备。
Explore whether plasma IL-6 levels are similar across biomarker platforms and association with COVID-19 clinical outcomes. Plasma IL-6 concentrations were measured on 191 COVID-19 patients using the Roche Elecsys IL-6 assay and the Meso Scale Discovery assay. Correlation of IL-6 levels between platforms was high (r = 0.87; 95% CI: 0.82–0.89); however, agreement was low (bias: 147.2 pg/ml; 95% limits of agreement: -489.5–783.9 pg/ml). The optimal IL-6 threshold to predict invasive mechanical ventilation and in-hospital mortality were 3- and 3.4-fold higher in Roche compared with Meso Scale Discovery, respectively. The absolute IL-6 threshold to predict outcomes was consistently higher using the Roche platform, and IL-6 thresholds to inform prognosis vary based on the biomarker platform. IL-6 levels in COVID-19 patients are correlated between two different biomarker platforms but the absolute IL-6 levels were consistently higher in samples measured using Roche versus the Meso Scale Discovery device.
影响因子：
9.8
作者：
Wang SY;Takahashi T;Pine AB;Damsky WE;Simonov M;Zhang Y;Kieras E;Price CC;King BA;Siegel MD;Desir GV;Lee AI;Iwasaki A;Chun HJ
通讯作者：
Chun HJ
DOI：
10.1093/rheumatology/keaa529
发表时间：
2020-12-01
期刊：
Rheumatology (Oxford, England)
影响因子：
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作者：
Nouri B;Nair N;Barton A
通讯作者：
Barton A